SynthesisJournal of psychosomatic research2022
Relationships between childhood trauma and multiple sclerosis: A systematic review.
Synthesis in Journal of psychosomatic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurotrauma and multiple sclerosis: the silent catalyst - a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies.Brain and behavior · 2023Pooled it
- The effect of education of self-care behaviors on the quality of life and resilience of multiple sclerosis patients.BMC neurology · 2024Trial
- Self-mastery buffers associations between stressful life events and mental quality of life and fatigue in people living with multiple sclerosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Adverse childhood experiences and risk of non-mental medical diseases in adulthood: an umbrella review.EClinicalMedicine · 2026Article
- Emotional Abuse and Psychological Distress in Individuals with Multiple Sclerosis: The Mediation Role of Internalized Shame and Chronic Illness Stigma.Behavioral sciences (Basel, Switzerland) · 2026Article
- Childhood adversity, allostatic load and epigenetic signatures in paediatric and adult-onset multiple sclerosis.Brain communications · 2026Article
- Childhood adversity and autoimmune diseases: global research landscape, immune-related hotspots, and emerging trends from a bibliometric analysis of three databases.Frontiers in immunology · 2026Article
- The Relation of Multiple Sclerosis to Family History, Lifestyle, and Health Factors in Childhood and Adolescence: Findings of a Case-Control Study Nested Within the German National Cohort (NAKO) Study.Deutsches Arzteblatt international · 2025Observational
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- Resilience, Mental Health, Sleep, and Smoking Mediate Pathways Between Lifetime Stressors and Multiple Sclerosis Severity.Sclerosis · 2024Article
- Contributions of Violence Exposure and Traumatic Stress Symptoms to Physical Health Outcomes in Incarcerated Adolescents.Youth & society · 2024Article
- Application value of machine learning models in predicting intraoperative hypothermia in laparoscopic surgery for polytrauma patients.World journal of clinical cases · 2024Article
- Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO).BMC neurology · 2024Article
- Management of Trauma-Induced Multiple Sclerosis with Paleo Diet and Integrative Therapies: A Case Report.Integrative medicine (Encinitas, Calif.) · 2024Article
- Intimate partner violence and multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Resilience, mental health, sleep, and smoking mediate pathways between lifetime stressors and Multiple Sclerosis severity.medRxiv : the preprint server for health sciences · 2024Article
- Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms.International journal of molecular sciences · 2024Review
- Addressing Smoking in Persons With Multiple Sclerosis: State of the Science and Need for a Targeted Intervention.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Lifetime stressors relate to invisible symptoms of multiple sclerosis.Exploration of neuroprotective therapy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveAdverse Childhood Experiences (ACEs), such as physical, emotional, and sexual abuse trigger inflammatory changes and have been associated with many causes of morbidity and mortality, including autoimmune diseases. Although Multiple Sclerosis (MS) is a debilitating neurological autoimmune disease, literature linking ACEs and MS is understudied. The aim of this review was to examine the 1) state of the literature, and 2) relationships between childhood adversity and the prevalence and physical clinical features of MS (e.g., age at onset, relapses, pain, fatigue, disability).
methodsA comprehensive search was preformed through five databases and by hand using the ancestry and descendancy approach for connections to papers published through January 20th, 2022. Studies were screened by independent reviewers using Rayyan.ai, and critically appraised for both quality and reporting transparency.
resultsTwelve studies examined relationships between any ACE(s) and the prevalence or physical clinical features of MS. There was considerable variance in the measurement of stressors, confounders, and categorization of MS; however most studies (n = 10) demonstrated an association between ACEs and MS (alone or grouped with other similar diagnoses), or physical clinical features.
conclusionAlthough there are few studies in this area, it is of quickly growing interest. These results should be cautiously interpreted, yet highlight the need for continued work to disentangle and discern true associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.