Evidence map›Paper›PMID 35779378›Full record

ArticleThrombosis research2022

Health-related quality of life associated with warfarin and direct oral anticoagulants in venous thromboembolism.

Margaret C Fang, Alan S Go, Priya A Prasad, Hui X Zhou, Anna L Parks, Dongjie Fan, Cecilia Portugal, Sue Hee Sung, Kristi Reynolds

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Margaret C FangDivision of Hospital Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: margaret.fang@ucsf.edu.
Alan S GoDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; Department of Medicine, Stanford University, Palo Alto, CA, USA.
Priya A PrasadDivision of Hospital Medicine, University of California, San Francisco, San Francisco, CA, USA.
Hui X ZhouDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Anna L ParksDivision of Hematology & Hematologic Malignancies, University of Utah, Salt Lake City, UT, USA.
Dongjie FanDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Cecilia PortugalDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Sue Hee SungDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Kristi ReynoldsDepartment of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Kaiser Permanente · USSan Francisco General Hospital · USUniversity of Utah · US

Funding

Use and outcomes of anticoagulants for the treatment and prevention of thrombosis among hospitalized patientsK24HL141354 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FANG, MARGARET C. · 2018 to 2022
$731k
Development and Preliminary Validation of a Bleeding Quality of Life PatientReported Outcome Measure for Older AdultsR03AG074074 · NIA · UNIVERSITY OF UTAH · PI PARKS, ANNA L · 2021 to 2022
$305k
NHLBI NIH HHS K24 HL141354NIA NIH HHS R03 AG074074
6 · The paper itself

Abstract

introductionVenous thromboembolism (VTE) is commonly treated with oral anticoagulants, including warfarin or direct oral anticoagulants (DOACs). Although DOACs are associated with favorable treatment satisfaction, few studies have assessed whether quality of life differs between DOAC and warfarin users. MATERIALS AND

methodsWe invited adults enrolled in two California-based integrated health care delivery systems and with a history of VTE between January 1, 2015 and June 30, 2018 to complete a survey on their experience with anticoagulants. Health-related quality of life (QOL) was assessed using the RAND 36-item Short Form Health Survey (SF-36), which measures QOL in 2 general component scores (physical and mental). We used multivariable linear regression to compare mean QOL component scores between DOAC-users and warfarin-users, adjusting for patient and clinical characteristics.

resultsOverall, 2230 patients (43.1 % women and 31.8 % >75 years of age) taking anticoagulants answered at least 1 question on the SF-36, 975 taking DOACs and 1255 taking warfarin. After adjustment for patient-level factors, there were no significant differences in either physical component scores (39.2 v 38.3, p = 0.24) or mental component scores (48.5 v 49.0, p = 0.42) between DOAC and warfarin users.

conclusionsHealth-related QOL did not significantly differ between DOAC and warfarin users with a history of VTE.

Indexed as

Venous ThromboembolismWarfarinAdministration, OralAdultAnticoagulantsFemaleHemorrhageHumansMaleQuality of LifeRetrospective StudiesAnticoagulantsWarfarinAnticoagulationDeep vein thrombosis (DVT)Pulmonary embolism (PE)Quality of lifeThrombosisVenous thromboembolism (VTE)

Identifiers

PMID35779378
PMCPMC10537975
OpenAlexW4283646828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.