Evidence map›Paper›PMID 35779327›Full record

ArticleSchizophrenia research2022

Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK biobank.

Matthew Bracher-Smith, Elliott Rees, Georgina Menzies, James T R Walters, Michael C O'Donovan, Michael J Owen, George Kirov, Valentina Escott-Price

Open access · hybridAbstract read
In one paragraph

Article in Schizophrenia research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  12. Identification of important gene signatures in schizophrenia through feature fusion and genetic algorithm.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Matthew Bracher-SmithMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK; Dementia Research Institute, Cardiff University, UK.
Elliott ReesMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK.
Georgina MenziesSchool of Biosciences, Cardiff University, UK.
James T R WaltersMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK.
Michael C O'DonovanMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK.
Michael J OwenMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK.
George KirovMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK.
Valentina Escott-PriceMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK. Electronic address: escottpricev@cardiff.ac.uk.
Cardiff University · GBUK Dementia Research Institute · GB

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/L010305/1Medical Research Council MR/L023784/2Medical Research Council MR/T04604X/1Medical Research Council UKDRI-3003
6 · The paper itself

Abstract

Machine learning (ML) holds promise for precision psychiatry, but its predictive performance is unclear. We assessed whether ML provided added value over logistic regression for prediction of schizophrenia, and compared models built using polygenic risk scores (PRS) or clinical/demographic factors. LASSO and ridge-penalised logistic regression, support vector machines (SVM), random forests, boosting, neural networks and stacked models were trained to predict schizophrenia, using PRS for schizophrenia (PRS

Indexed as

SchizophreniaBiological Specimen BanksDemographyHumansMachine LearningUnited KingdomMachine learningPolygenic risk scoresPrecision psychiatrySchizophrenia

Identifiers

PMID35779327
PMCPMC9399753
OpenAlexW4283725898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.