Evidence map›Paper›PMID 35779248›Full record

ArticleJournal of diabetes investigation2022

Analysis of clinical phenotypes of neuropathic symptoms in patients with type 2 diabetes: A multicenter study.

Yu Ji Kim, Jeong Min Lee, Chang Won Lee, Choon Hee Chung, Jae Hyuk Lee, Seung Hyun Ko, Dong Hyeok Cho, Ji Hyun Lee, Ho Chan Cho, Sang Soo Kim and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yu Ji KimDepartment of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National University Medical School-Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, South Korea.ORCID https://orcid.org/0000-0003-4100-5839
Jeong Min LeeDepartment of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
Chang Won LeeDepartment of Internal Medicine, Busan St. Mary's Hospital, Busan, South Korea.
Choon Hee ChungDepartment of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Jae Hyuk LeeDepartment of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea.
Seung Hyun KoDepartment of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea.ORCID https://orcid.org/0000-0003-3703-1479
Dong Hyeok ChoDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Ji Hyun LeeDepartment of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea.
Ho Chan ChoDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea.
Sang Soo KimDepartment of Internal Medicine, Pusan National University Hospital, Busan, South Korea.
Chong Hwa KimDepartment of Internal Medicine, Sejong General Hospital, Bucheon, South Korea.
Jong Chul WonDepartment of Internal Medicine, Cardiovascular and Metabolic Disease Center, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, South Korea.ORCID https://orcid.org/0000-0002-2219-4083
Tae Sun ParkDepartment of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National University Medical School-Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, South Korea.ORCID https://orcid.org/0000-0001-7216-8468

Funding

Korean Diabetes Association 2017S-3
6 · The paper itself

Abstract

AIMS/

introductionWe investigated the classification of diabetic peripheral neuropathy (DPN) patients by subjective symptoms, and identification of the relationship between the patterns and intensities of symptoms and the clustered groups of DPN patients. MATERIALS AND

methodsThis multicenter study analyzed epidemiological data and sensory symptoms of 649 patients with DPN. Cluster analysis was carried out to identify subgroups of patients with characteristic symptom profiles. Factor analysis was carried out to investigate the symptom patterns of the clustered groups of DPN patients.

resultsThree clusters of patients with DPN were identified: severe symptoms with decreased quality of life (cluster 1, n = 119, 18.3%), predominantly insensate symptoms with relatively good quality of life (cluster 2, n = 318, 49.0%), and moderate pain intensity and decreased quality of life (cluster 3, n = 204, 31.4%). The frequency of symptoms on each item of the Michigan Neuropathy Screening Instrument questionnaire showed a similar distribution according to pain intensities along with the three clusters.

conclusionsOur study supports the hypothesis that diversity in sensory symptoms exists in patients with DPN. Heterogeneity in DPN patients should be taken into account for a more stratified or individualized treatment approach. Based on a multicenter study, we identified three clusters of patients with DPN. Our research supports the hypothesis that diversity in sensory symptoms exists in patients with DPN. Heterogeneity in DPN patients should be taken into account for a more stratified or individualized treatment approach.

Indexed as

Diabetes Mellitus, Type 2Diabetic NeuropathiesHumansPainPhenotypeQuality of LifeDiabetes mellitus, type 2Diabetic neuropathiesPhenotype

Identifiers

PMID35779248
PMCPMC9623523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.