ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022
Prognostic factors for renal function deterioration during palliative first-line chemotherapy for metastatic colorectal cancer: a retrospective study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 10 citations in OpenAlex.
- Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib.Journal of clinical pharmacology · 2025Article
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5 authors at 1 institution in 2 countries.
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Abstract
purposeFirst-line choice of therapy is critical as it affects treatment decisions in later lines in patients with metastatic colorectal cancer (mCRC). We assessed changes in renal function for 1 year among patients diagnosed with mCRC who received first-line chemotherapy. We aimed to analyze the prognostic factors and effect of each chemotherapy regimen on the renal function of the patients.
methodsWe retrospectively investigated patients with mCRC who were treated with a standard triplet regimen (FOLFOX/FOLFIRI with bevacizumab/cetuximab) in the first-line setting at Korea University Anam Hospital from 2015 to 2020. We checked renal function at 3-month intervals for 12 months. We calculated changes in eGFR (△eGFR, estimated glomerular filtration rate) and compared them with clinical factors such as age, sex, chronic disease, body mass index (BMI), disease status, baseline proteinuria, and first-line chemotherapy regimen.
resultsAmong 472 patients with mCRC, the median eGFR at baseline was 90.9 mL/min/1.73 m
conclusionsThese findings can serve as important factors when selecting the first-line chemotherapy regimen for patients with mCRC.
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