Evidence map›Paper›PMID 35779120›Full record

ArticleParasitology research2022

Population replacement of benzimidazole-resistant Haemonchus contortus with susceptible strains: evidence of changes in the resistance status.

Sebastián Muchiut, César Fiel, Juan Pedro Lirón, Mercedes Lloberas, Carolina Ceriani, Ramiro Lorenzo, Eliana Riva, Gisele Bernat, Patricia Cardozo, Silvina Fernández and 1 more

Abstract read
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In one paragraph

Article in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sebastián MuchiutÁrea de Parasitología y Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pje. Arroyo Seco s/n, B7000, Tandil, Argentina. smuchiut@vet.unicen.edu.ar.
César FielÁrea de Parasitología y Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pje. Arroyo Seco s/n, B7000, Tandil, Argentina.
Juan Pedro LirónCentro de Investigación Veterinaria de Tandil (CIVETAN) (UNCPBA-CICPBA-CONICET), Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina.
Mercedes LloberasInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS Balcarce) EEA-INTA, Balcarce, Argentina.
Carolina CerianiCentro de Investigación Veterinaria de Tandil (CIVETAN) (UNCPBA-CICPBA-CONICET), Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina.
Ramiro LorenzoCentro de Investigación Veterinaria de Tandil (CIVETAN) (UNCPBA-CICPBA-CONICET), Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina.
Eliana RivaÁrea de Parasitología y Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pje. Arroyo Seco s/n, B7000, Tandil, Argentina.
Gisele BernatÁrea de Parasitología y Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pje. Arroyo Seco s/n, B7000, Tandil, Argentina.
Patricia CardozoInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS Balcarce) EEA-INTA, Balcarce, Argentina.
Silvina FernándezÁrea de Parasitología y Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pje. Arroyo Seco s/n, B7000, Tandil, Argentina.
Pedro SteffanÁrea de Parasitología y Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pje. Arroyo Seco s/n, B7000, Tandil, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spread of anthelmintic resistance (AR) in nematode populations threatens the viability of sheep production systems worldwide, and warrants the adoption of sensitive, practical, and standardized tests to detect AR. The aim of this study was to characterize the replacement of an Haemonchus contortus population resistant to benzimidazoles (BZDs) by a susceptible one, by means of both phenotypic and genotypic techniques. Phenotypic methods to assess BZD resistance included in vivo tests, such as the fecal egg count reduction test (FECRT), and in vitro tests, such as the egg hatch assay (EHA). Additionally, genotypification of polymorphisms associated with BZD resistance by sequencing a fragment of the isotype 1 β-tubulin gene was carried out. The initial, BZD-resistant population (initial Balcarce population) exhibited an egg count reduction (ECR) of 59.3%. Following refugium replacement, the final population (final Balcarce population) exhibited an ECR of 95.2%. For the initial Balcarce population, the median effective dose (ED

Indexed as

AnthelminticsHaemonchiasisHaemonchusSheep DiseasesAnimalsBenzimidazolesDrug ResistancePopulation DynamicsSheepThiabendazoleTubulinAnthelminticsBenzimidazolesThiabendazoleTubulinAnthelmintic resistanceBenzimidazolesDiagnostic methodsHaemonchus contortusPopulation replacement

Identifiers

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Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.