Evidence map›Paper›PMID 35779115›Full record

ArticleLasers in medical science2022

Visualization of ex vivo rabbit olfactory mucosa and foramina with three-dimensional optical coherence tomography.

Tiffany Thienthao Pham, Andrew Emon Heidari, Amir Aaron Hakimi, Yan Li, Cameron Michael Heilbronn, Ellen Minyoung Hong, Ji-Hun Mo, Edward Cheng-Lung Kuan, Zhongping Chen, Brian Jet-Fei Wong

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Tiffany Thienthao PhamBeckman Laser Institute & Medical Clinic, University of California - Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-0308-4540
Andrew Emon HeidariBeckman Laser Institute & Medical Clinic, University of California - Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-3982-128X
Amir Aaron HakimiBeckman Laser Institute & Medical Clinic, University of California - Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-5675-5758
Yan LiBeckman Laser Institute & Medical Clinic, University of California - Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-3468-9235
Cameron Michael HeilbronnBeckman Laser Institute & Medical Clinic, University of California - Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-3108-9549
Ellen Minyoung HongBeckman Laser Institute & Medical Clinic, University of California - Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-0084-2924
Ji-Hun MoBeckman Laser Institute - Korea, Dankook University, Cheonan, Chungnam, Republic of Korea.ORCID http://orcid.org/0000-0003-1331-364X
Edward Cheng-Lung KuanDepartment of Otolaryngology - Head and Neck Surgery, University of California - Irvine, School of Medicine, Orange, CA, USA.ORCID http://orcid.org/0000-0003-3475-0718
Zhongping ChenBeckman Laser Institute & Medical Clinic, University of California - Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-4584-4560
Brian Jet-Fei WongBeckman Laser Institute & Medical Clinic, University of California - Irvine, Irvine, CA, USA. bjwong@uci.edu.ORCID http://orcid.org/0000-0001-6318-7384
University of California, Irvine · USDankook University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing interest in developing a minimally invasive imaging modality to safely evaluate dynamic microscopic changes of the olfactory mucosa and cribriform foramina. Herein, we utilized three-dimensional (3D) optical coherence tomography (OCT) to characterize the ex vivo stratified substructure of olfactory mucosa in rabbits and create 3D reconstructed images of olfactory foramina. Olfactory mucosa and cribriform plates from four New Zealand White rabbits were dissected and imaged using two swept-source OCT systems: (1) 1.3-µm (μm) center wavelength, 100-nm bandwidth, 200-kHz sweep rate, and (2) 1.7-μm center wavelength, 120-nm bandwidth, 90-kHz sweep rate. Volumetric OCT images were compiled to create a 3D reconstruction of the cribriform plate. The ability of OCT to distinguish the olfactory mucosa substructure and foramina was compared to histology. To estimate imaging penetration depth of each system, the first-order exponential decays of depth-resolved intensity were calculated and compared using a paired t-test. Three-dimensional OCT depicted the stratified layered structures within the olfactory mucosa correlating with histology. The epithelium and lamina propria were measured to be 32 μm and 107 μm in 1.3-μm OCT compared to 30 μm and 105 μm in histology. Olfactory foramina were visualized via 3D reconstruction. The 1.7-μm system provided greater depth penetration compared to the 1.3-μm system, allowing for improved foramina visualization. We have shown that OCT can be used to image non-pathologic olfactory mucosa and foramina. Implications for this work include diagnostic and therapeutic potentials for neurorhinological and neurodegenerative diseases.

Indexed as

Imaging, Three-DimensionalTomography, Optical CoherenceAnimalsEpitheliumOlfactory MucosaRabbitsAnterior skull baseCribriform plateOlfactory cleftOlfactory foraminaOlfactory mucosaOptical coherence tomography

Identifiers

PMID35779115
OpenAlexW4283773855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.