Evidence map›Paper›PMID 35779091›Full record

ArticleEuropean radiology2022

First-pass perfusion cardiovascular magnetic resonance parameters as surrogate markers for left ventricular diastolic dysfunction: a validation against cardiac catheterization.

Xinli Guo, Chao Gong, Rizhen Song, Ke Wan, Yuchi Han, Yucheng Chen

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In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. [Using CT to Evaluate Cardiac Function].Journal of the Korean Society of Radiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xinli Guo *Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.
Chao Gong *Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.
Rizhen Song *Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.
Ke WanDepartment of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.
Yuchi HanDepartment of Medicine (Cardiovascular Division), University of Pennsylvania, Philadelphia, PA, USA.
Yucheng ChenDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China. chenyucheng2003@126.com.ORCID http://orcid.org/0000-0001-8480-4054
Sichuan University · CNUniversity of Pennsylvania · US

Funding

the 1·3·5 Project for Disciplines of Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University No. ZYJC18013 and No. Z2018A08
6 · The paper itself

Abstract

objectivesThe non-invasive assessment of left ventricular (LV) diastolic dysfunction remains a challenge. The role of first-pass perfusion cardiac magnetic resonance (CMR) parameters in quantitative hemodynamic analyses has been reported. We therefore aimed to validate the diagnostic ability and accuracy of such parameters against cardiac catheterization for LV diastolic dysfunction in patients with left heart disease (LHD).

methodsWe retrospectively enrolled 77 LHD patients who underwent CMR imaging and cardiac catheterization. LV diastolic dysfunction was defined as pulmonary capillary wedge pressure (PCWP) or LV end-diastolic pressure (LVEDP) > 12 mmHg on catheterization. On first-pass perfusion CMR imaging, pulmonary transit time (PTT) was measured as the time for blood to pass from the left ventricle to the right ventricle (RV) through the pulmonary vasculature. Pulmonary transit beat (PTB) was the number of cardiac cycles within the interval, and pulmonary blood volume indexed to body surface area (PBVi) was the product of PTB and RV stroke volume index (RVSVi).

resultsOf the 77 LHD patients, 53 (68.83%) were found to have LV diastolic dysfunction, and showed significantly higher PTTc, PTB, and PBVi (p < 0.05) compared with those without. In multivariate analyses, only PTTc and PTB were identified as independent predictors of LV diastolic dysfunction (p < 0.05). With an optimal cutoff of 11.9 s, PTTc yielded the best diagnostic performance for LV diastolic dysfunction (area under the curve = 0.83, p < 0.001).

conclusionsPTTc may represent a non-invasive quantitative surrogate marker for the detection and assessment of diastolic dysfunction in LHD patients. KEY POINTS: • PTTc yielded the best diagnostic accuracy for diastolic dysfunction, with an optimal cutoff of 11.9 s, and a specificity of 100%. • PTTc and PTB were found to be independent predictors of LV diastolic dysfunction across different multivariate models with high reproducibility. • PTTc is a promising non-invasive surrogate marker for the detection and assessment of diastolic dysfunction in LHD patients.

Indexed as

Ventricular Dysfunction, LeftVentricular Function, LeftBiomarkersCardiac CatheterizationHumansMagnetic Resonance Imaging, CineMagnetic Resonance SpectroscopyPerfusionReproducibility of ResultsRetrospective StudiesStroke VolumeBiomarkersCardiac catheterizationCardiomyopathiesMagnetic resonance imagingVentricular dysfunction, left

Identifiers

PMID35779091
OpenAlexW4283768483

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.