Evidence map›Paper›PMID 35779085›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2022

Pandemic COVID-19, an update of current status and new therapeutic strategies.

Antonio Vitiello, Raffaele La Porta, Ugo Trama, Francesco Ferrara, Andrea Zovi, Amogh Milind Auti, Marina Di Domenico, Mariarosaria Boccellino

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. COVID-19 Pandemic: Therapeutic Strategies and Vaccines.International journal of molecular sciences · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Pharmacological Agents with Antiviral Activity against Monkeypox Infection.International journal of molecular sciences · 2022
    Review
  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antonio VitielloPharmaceutical Department, Usl Umbria 1, Via XIV Settembre, 06132, Perugia, Italy.
Raffaele La PortaClinical Pathologist, Pathology Department, ASUR Marche, Area Vasta 1, Urbino, Italy.
Ugo TramaDirectorate General for Healthcare and Coordination of the Regional Healthcare System, Naples, Italy.
Francesco FerraraPharmaceutical Department, Asl Napoli 3 Sud, Via Dell'amicizia 22, 80035, Naples, Nola, Italy. ferrarafr@libero.it.ORCID http://orcid.org/0000-0001-9298-6783
Andrea ZoviMinistry of Health, Viale Giorgio Ribotta 5, 00144, Rome, Italy.
Amogh Milind AutiDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
Marina Di DomenicoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
Mariarosaria BoccellinoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global COVID-19 pandemic is underway. In recent weeks, several countries throughout the globe, and particularly in Europe, have experienced an exponential increase in the number of individuals infected with COVID-19, probably induced by a new variant of SARS-CoV-2, called the "Omicron variant." Mass vaccination against COVID-19 continues worldwide. Are authorized mRNA vaccines effective against the new Omicron variant? Recently, several pharmaceutical companies have developed oral antiviral pills against SARS-CoV-2, i.e., molnupiravir and paxlovid, that inhibit SARS-CoV-2 viral replication by acting on the RNA polymerase of SARS-CoV. In pre-registration clinical trials, molnupiravir and paxlovid have shown excellent clinical efficacy results, but what impact will these new oral antiviral agents have against pandemic COVID-19? In what specific clinical situations are they preferred over other antivirals such as remdesivir? In this brief review, we explore these important aspects.

Indexed as

COVID-19 Drug TreatmentPandemicsAntiviral AgentsHumansSARS-CoV-2Antiviral AgentsAntiviralCOVID-19OmicronTherapeuticVariants

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.