Evidence map›Paper›PMID 35779081›Full record

Observational studyInternational journal of colorectal disease2022

Surgical treatment of rectovaginal fistula-predictors of outcome and effects on quality of life.

Erik V Söderqvist, Peter H Cashin, Wilhelm Graf

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05006586 (Rectovaginal Fistula Repair Predictors of Outcome and Results After Surgical Management), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05006586 completednot on this map

Rectovaginal Fistula Repair Predictors of Outcome and Results After Surgical Management

TypeobservationalSponsorUppsala UniversityRan2020 to 2021Enrolled55ConditionsFistula Vagina, Fistula, Rectal
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Observational
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erik V SöderqvistDepartment of Surgical Sciences, Uppsala University, 75185, Uppsala, Sweden. Erik.soederqvist@gmail.com.
Peter H CashinDepartment of Surgical Sciences, Uppsala University, 75185, Uppsala, Sweden.
Wilhelm GrafDepartment of Surgical Sciences, Uppsala University, 75185, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the results after rectovaginal fistula (RVF) repair and find predictors of outcome. Primary objective was fistula healing. Secondary outcomes were morbidity and patient health-related quality of life (HRQoL).

methodAn observational study of 55 women who underwent RVF repair including both local procedures and tissue transposition 2003-2018 was performed. Baseline patient and fistula characteristics were registered, combined with a prospective HRQoL follow-up and a general questionnaire describing fistula symptoms.

resultsHealing rate after index surgery was 25.5% (n = 14) but the final healing rate was 67.3% (n = 37). Comparing the etiologies, traumatic fistulas (iatrogenic and obstetric) had the highest healing rates after index surgery (n = 11, 45.9%) and after repeated operations at final follow-up (n = 22, 91.7%) compared with fistulas of inflammatory fistulas (Crohn's disease, cryptoglandular infection, and anastomotic leakage) that had inferior healing rates after both index surgery (n = 7, 7.1%) and at final follow-up (n = 13, 46.4%). Fistulas of the category others (radiation damage and unknown etiology) included a small amount of patients with intermediate results at both index surgery (n = 1, 33.3%) and healing rate at last follow-up (n = 2, 66.7%). The differences were statistically significant for both index surgery (p = 0.004) and at final follow-up (p = 0.001). Unhealed patients scored lower than both healed patients and the normal population in 6/8 Rand-36 domains, but the differences were not statistically significant.

conclusionsMost traumatic rectovaginal fistulas closed after repeated surgery whereas inflammatory fistulas had a poor prognosis. Low healing rates after local repairs suggest that tissue transfer might be indicated more early in the treatment process. Unhealed fistulas were associated with reduced quality of life. Trial registration Clinicaltrials.gov No. NCT05006586.

Indexed as

Crohn DiseaseRectovaginal FistulaFemaleHumansPregnancyProspective StudiesQuality of LifeTreatment OutcomeColorectal diseasesColorectal surgeryQuality of lifeRectovaginal fistulaVaginal diseases

Identifiers

PMID35779081
PMCPMC9262790

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.