ArticleMolecular biology and evolution2022
Warthog Genomes Resolve an Evolutionary Conundrum and Reveal Introgression of Disease Resistance Genes.
Article in Molecular biology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- From forests to deserts: Sequencing of the giant forest hog completes the genomic history of the African suids.iScience · 2026Article
- The influence of structural variants from 2445 pigs on gene expression and complex traits.Nature communications · 2026Article
- Large-scale genomic phylogeography provides insights into evolutionary history and conservation priorities of the white-bellied pangolin (Phataginus tricuspis).Molecular biology and evolution · 2026Article
- Integrated multi-omics profiling identifies genetic loci of African swine fever resistance in pigs.GigaScience · 2026Article
- Population structure and domestication history of the Javan banteng.Current biology : CB · 2026Article
- Innate resistance to African swine fever virus: current knowledge and future directions.BMC veterinary research · 2025Review
- Different Strokes for Different Croaks: Using an African Reed Frog Species Complex as a Model to Understand Idiosyncratic Population Requirements for Conservation Management.Evolutionary applications · 2025Article
- Comparative genomics provides insights into chromosomal evolution and immunological adaptation in horseshoe bats.Nature ecology & evolution · 2025Article
- Persistent Gene Flow Suggests an Absence of Reproductive Isolation in an African Antelope Speciation Model.Systematic biology · 2024Article
- A comprehensive atlas of nuclear sequences of mitochondrial origin (NUMT) inserted into the pig genome.Genetics, selection, evolution : GSE · 2024Article
- Integrating Multiple Database Resources to Elucidate the Gene Flow in Southeast Asian Pig Populations.International journal of molecular sciences · 2024Article
- Introgression and disruption of migration routes have shaped the genetic integrity of wildebeest populations.Nature communications · 2024Article
- Genetic diversity of lion populations in Kenya: Evaluating past management practices and recommendations for future conservation actions.Evolutionary applications · 2024Article
- African bushpigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival.Nature communications · 2024Article
- An Updated Review ofPathogens (Basel, Switzerland) · 2023Review
- African Suid Genomes Provide Insights into the Local Adaptation to Diverse African Environments.Molecular biology and evolution · 2022Article
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14 authors.
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Abstract
African wild pigs have a contentious evolutionary and biogeographic history. Until recently, desert warthog (Phacochoerus aethiopicus) and common warthog (P. africanus) were considered a single species. Molecular evidence surprisingly suggested they diverged at least 4.4 million years ago, and possibly outside of Africa. We sequenced the first whole-genomes of four desert warthogs and 35 common warthogs from throughout their range. We show that these two species diverged much later than previously estimated, 400,000-1,700,000 years ago depending on assumptions of gene flow. This brings it into agreement with the paleontological record. We found that the common warthog originated in western Africa and subsequently colonized eastern and southern Africa. During this range expansion, the common warthog interbred with the desert warthog, presumably in eastern Africa, underlining this region's importance in African biogeography. We found that immune system-related genes may have adaptively introgressed into common warthogs, indicating that resistance to novel diseases was one of the most potent drivers of evolution as common warthogs expanded their range. Hence, we solve some of the key controversies surrounding warthog evolution and reveal a complex evolutionary history involving range expansion, introgression, and adaptation to new diseases.
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