Evidence map›Paper›PMID 35778961›Full record

ArticleImmunology2022

Conditional knockout of oestrogen receptor alpha in CD11c

Mara L Lennard Richard, Jena R Wirth, Aastha Khatiwada, Dongjun Chung, Gary S Gilkeson, Melissa A Cunningham

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mara L Lennard RichardDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Jena R WirthDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Aastha KhatiwadaDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Dongjun ChungDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Gary S GilkesonDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Melissa A CunninghamDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0002-9207-1986
Medical University of South Carolina · USThe Ohio State University · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jian Ouyang · 2009 to 2026
$42.7M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
Molecular mechanisms of estrogen receptor alpha modulating the inflammatory response in systematic lupus erythematosusK08AR068471 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CUNNINGHAM, MELISSA A · 2016 to 2020
$861k
South Carolina Clinical & Translational Research Institute (SCTR)KL2TR000060 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$807k
NCATS NIH HHS KL2 TR000060NCATS NIH HHS UL1 TR000062NCI NIH HHS P30 CA138313NIAMS NIH HHS K08 AR068471NIMHD NIH HHS L60 MD005574
6 · The paper itself

Abstract

Oestrogen and oestrogen receptor alpha (ERα) have been implicated in systemic lupus erythematosus pathogenesis. ERα signalling influences dendritic cell (DC) development and function, as well as inflammation and downstream immune responses. We previously reported that ERα modulates multiple Toll-like receptor-stimulated pathways in both conventional and plasmacytoid DCs in lupus-prone mice. For example, CD11c

Indexed as

Estrogen Receptor alphaInterleukin-17AnimalsCD11c AntigenDendritic CellsEstrogensFemaleInflammationInterferonsMiceToll-Like ReceptorsCD11c AntigenEstrogen Receptor alphaEstrogensInterferonsInterleukin-17Toll-Like Receptorscytokinesdendritic cellsoestrogen receptor alpha (ERα)systemic lupus erythematosus (SLE)Toll-like receptors

Identifiers

PMID35778961
PMCPMC9562028
OpenAlexW4283774679

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.