ArticleWorld journal of surgical oncology2022
Prognostic significance of 4R lymph node dissection in patients with right primary non-small cell lung cancer.
Article in World journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06496360 (Prediction Model of Mediastinal Group IV Lymph Node Metastasis in Non-small Cell Lung Cancer Based on CT Radiomics), which is not on this map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prediction Model of Mediastinal Group IV Lymph Node Metastasis in Non-small Cell Lung Cancer Based on CT Radiomics
Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Computed tomography-based radiomics model for predicting station 4 lymph node metastasis in non-small cell lung cancer.BMC medical imaging · 2025Article
- The prognostic significance of right paratracheal lymph node dissection numbers in right upper lobe non-small cell lung cancer.Updates in surgery · 2024Article
- Lymph node dissection of station 8 improves the survival of TTranslational lung cancer research · 2024Article
- Two Interventions on Pathologic Nodal Staging in a Population-Based Lung Cancer Resection Cohort.The Annals of thoracic surgery · 2024Article
- Clinical value of station 4R node dissection in esophageal squamous cell carcinoma.World journal of surgical oncology · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the prognostic significance of station 4R lymph node (LN) dissection in patients who underwent operations for right primary non-small cell lung cancer (NSCLC).
methodsWe performed a retrospective study involving patients with right primary NSCLC who received lobotomy or pneumonectomy with mediastinal LN dissection between January 2011 and December 2017. Propensity score matching was performed. Disease-free survival (DFS) and overall survival (OS) were compared between patients with and without station 4R dissection.
resultsOur study included 2070 patients, with 207 patients having no station 4R dissection (S4RD- group) and 1863 patients having station 4R dissection (S4RD+ group). The 4R LN metastasis rate was 13.4% (142/1748), higher than that for other mediastinal LN metastases. Compared with the S4RD- group, the S4RD+ group had higher 5-year DFS (48.1% vs. 39.1%, P = 0.009) and OS (54.4% vs. 42.8%, P = 0.025). Station 4R dissection was an independent risk factor for DFS (odds ratio, OR, 1.28, 95% confidence interval, CI, 1.08-1.64, P = 0.007) and OS (OR 1.31, 95% CI 1.04-1.63, P = 0.018). Patients with adjuvant chemotherapy had a better prognosis after station 4R dissection than those without adjuvant chemotherapy (57.4% vs. 52.3%, P = 0.006). The 5-year OS in the station 4R metastasis group was lower than that in the station 4R non-metastasis group (26.9% vs. 44.3%, P = 0.006) among N2 patients. The 5-year OS of the single-station 4R metastasis group was lower than that of the single-station 7 metastasis group (15.7% vs. 51.6%, P = 0.002).
conclusionsStation 4R metastasis was the highest among all the mediastinal station metastases in right primary NSCLC patients. Station 4R dissection can improve the prognosis and should be recommended as a routine procedure for these patients.
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