ArticleBMC geriatrics2022
The transitions and predictors of cognitive frailty with multi-state Markov model: a cohort study.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Prediction model for cognitive frailty in older adults: A systematic review and critical appraisal.Frontiers in aging neuroscience · 2023Pooled it
- Associations of malnutrition and hydration status with cognitive frailty in older adults.European geriatric medicine · 2026Article
- Associations of cognitive impairment and physical disability with the risk and reversibility of depressive symptoms in Chinese older adults.BMC geriatrics · 2026Observational
- Activity profiles and their associations with transitions between fall and dementia: findings from a multistate time-to-event analysis.Alzheimer's research & therapy · 2026Article
- Predicting cognitive frailty in older adults: an explainable machine learning model integrating radiomics and clinical features.BMC medical informatics and decision making · 2026Article
- Progression and influencing factors of knee osteoarthritis based on a multi-state Markov model: Data from OAI.Osteoarthritis and cartilage open · 2026Article
- Development and validation of a prediction model for long-term cognitive frailty risk in stroke patients based on CHARLS data.PloS one · 2026Article
- Transitions across the cognitive frailty spectrum and its association with anxiety in individuals aged 55 years and over: a 7 years longitudinal study.Scientific reports · 2025Article
- Air pollution and dynamic transitions of preserved ratio impaired spirometry in UK Biobank.Communications medicine · 2025Article
- The independent association of social isolation and loneliness with cognitive frailty in Chinese older adults: a cross-sectional study.BMC public health · 2025Article
- The relationship between frailty and multimorbidity in Chinese older adults: the chain mediating effects of sleep quality and anxiety.BMC geriatrics · 2025Article
- Multistate Markov model for functional recovery in stroke: probability of state transition and prognosis prediction.Scientific reports · 2025Article
- Article
- Prevalence and associated factors of cognitive frailty in older patients with lung cancer undergoing chemotherapy: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Longitudinal Trajectories of Cognitive Function Among Chinese Middle-Aged and Older Adults: The Role of Sarcopenia and Depressive Symptoms.Brain sciences · 2025Article
- Association of multimorbidity patterns and order of physical frailty and cognitive impairment occurrence: a prospective cohort study.Age and ageing · 2025Article
- Association between household solid fuel use and cognitive frailty in a middle-aged and older Chinese population.Frontiers in public health · 2025Article
- Association of sleep duration and sleep quality with cognitive frailty in Chinese older adults.Frontiers in public health · 2025Article
- Prevalence of cognitive frailty and its associated factors in a population of Iranian older adults.Aging clinical and experimental research · 2024Article
- Factors affecting cognitive frailty improvement and progression in Taiwanese older adults.BMC geriatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive frailty (CF) is characterized by the simultaneous presence of physical frailty and cognitive impairment. Previous studies have investigated its prevalence and impact on different adverse health-related outcomes. Few studies have focused on the progression and reversibility of CF and their potential predictors.
methodsData were derived from the China Health and Retirement Longitudinal Study (CHARLS). A total of 4051 older adults with complete data on three waves of the survey (2011, 2013, and 2015) were included and categorized into four groups: normal state (NS), cognitive impairment (CI) only, physical frailty (PF) only and CF (with both PF and CI). A multi-state Markov model was constructed to explore the transitions and predicting factors of CF.
resultsThe incidence and improvement rates of CF were 1.70 and 11.90 per 100 person-years, respectively. The 1-year transition probability of progression to CF in those with CI was higher than that in the PF population (0.340 vs. 0.054), and those with CF were more likely to move to PF (0.208). Being female [hazard ratio (HR) = 1.46, 95%CI = 1.06, 2.02)], dissatisfied with life (HR = 4.94, 95%CI = 1.04, 23.61), had a history of falls (HR = 2.36, 95%CI = 1.02, 5.51), rural household registration (HR = 2.98, 95%CI = 1.61, 5.48), multimorbidity (HR = 2.17, 95%CI = 1.03, 4.59), and depression (HR = 1.75, 95%CI = 1.26, 2.45) increased the risk of progression to CF, whereas literacy (HR = 0.46, 95%CI = 0.33, 0.64) decreased such risk. Depression (HR = 0.43, 95%CI = 0.22, 0.84) reduced the likelihood of CF improvement, whereas literacy (HR = 2.23, 95%CI = 1.63, 3.07) increased such likelihood.
conclusionsCognitive frailty is a dynamically changing condition in older adults. Possible interventions aimed at preventing the onset and facilitating the recovery of cognitive frailty should focus on improving cognitive function in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.