Evidence map›Paper›PMID 35778603›Full record

ArticleScientific reports2022

Resting-state functional connectivity of salience network in schizophrenia and depression.

Huan Huang, Cheng Chen, Bei Rong, Qirong Wan, Jingang Chen, Zhongchun Liu, Yuan Zhou, Gaohua Wang, Huiling Wang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Post-COVID-19 conditions: a systematic review on advanced magnetic resonance neuroimaging findings.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  2. Trial
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  5. Article
  6. Article
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  9. Age-Related Hearing Decline and Resting-State Networks.American journal of audiology · 2025
    Article
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  11. Article
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  14. Review
  15. Article
  16. Article
  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Huan HuangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Cheng ChenDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Bei RongDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Qirong WanDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Jingang ChenDepartment of Psychiatry, Zhongxiang Hospital of Renmin Hospital of Wuhan University, Zhongxiang, 431900, China.
Zhongchun LiuDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Yuan ZhouInstitute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.
Gaohua WangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Huiling WangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, China. hlwang@whu.edu.cn.
Renmin Hospital of Wuhan University · CNWuhan University · CNInstitute of Psychology, Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the salience network (SN) functional alterations in schizophrenia and depression, resting-state functional magnetic resonance imaging (rs-fMRI) data from 29 patients with schizophrenia (SCH), 28 patients with depression (DEP) and 30 healthy controls (HC) were obtained. The SN was derived from data-driven group independent component analysis (gICA). ANCOVA and post hoc tests were performed to discover the FC differences of SN between groups. The ANCOVA demonstrated a significant group effect in FC with right inferior and middle temporal gyrus (ITG and MTG), left caudate, and right precentral gyrus. Post-hoc analyses revealed an opposite altered FC pattern between SN and right ITG and MTG for both patient groups. The DEP group showed a reduced FC between SN and right ITG and MTG compared with HC whereas the SCH group showed an increased FC. In addition, the SCH group showed decreased FC between SN and left caudate, and enhanced FC between SN and right precentral gyrus compared to the other two groups. Our findings suggest distinct FC of SN in schizophrenia and depression, supporting that the resting-state FC pattern of SN may be a transdiagnostic difference between depression and schizophrenia and may play a critical role in the pathogenesis of these two disorders.

Indexed as

SchizophreniaCorrelation of DataDepressionHumansTemporal Lobe

Identifiers

PMID35778603
PMCPMC9249853
OpenAlexW4283782021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.