Evidence map›Paper›PMID 35778599›Full record

ReviewMucosal immunology2022

Immunosurveillance of Candida albicans commensalism by the adaptive immune system.

Marc Swidergall, Salomé LeibundGut-Landmann

Open access · hybridAbstract readReview
In one paragraph

Review in Mucosal immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 42 citations in OpenAlex.

  1. A Synthetic β-Mannan Epitope Enables Immunization and Detection of Candida auris.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Microbiota and cancer: Elucidating the role ofWorld journal of clinical oncology · 2025
    Review
  9. Candida albicans: the current status regarding vaginal infections.Applied microbiology and biotechnology · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Evaluating the Role ofInterdisciplinary perspectives on infectious diseases · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. ControllingInfection and immunity · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Marc SwidergallDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Salomé LeibundGut-LandmannSection of Immunology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland. salome.leibundgut-landmann@uzh.ch.ORCID http://orcid.org/0000-0002-5724-4837
University of California, Los Angeles · USUniversity of Zurich · CH

Funding

Oral commensal fungi and structural immunityR01DE031382 · NIDCR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Marc Swidergall · 2022 to 2026
$2.5M
Novel Candida albicans host receptors during infection and immune responseR00DE026856 · NIDCR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI SWIDERGALL, MARC · 2019 to 2021
$710k
NIDCR NIH HHS R00 DE026856NIDCR NIH HHS R01 DE031382
6 · The paper itself

Abstract

The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is involved in many key aspects of human physiology, while an imbalance of the fungal communities, termed fungal dysbiosis, has been described in pathologies ranging from infections to inflammatory bowel disease. Commensal organisms, such as the fungus Candida albicans, induce antigen-specific immune responses that maintain immune homeostasis. Adaptive immune mechanisms are vital in this process, while deficiencies in adaptive immunity are linked to fungal infections. We start to understand the mechanisms by which a shift in mycobiota composition, in particular in C. albicans abundance, is linked to immunopathological conditions. This review discusses the mechanisms that ensure continuous immunosurveillance of C. albicans during mucosal colonization, how these protective adaptive immune responses can also promote immunopathology, and highlight therapeutic advances against C. albicans-associated disease.

Indexed as

Candida albicansSymbiosisDysbiosisHumansImmune SystemMonitoring, Immunologic

Identifiers

PMID35778599
PMCPMC9385492
OpenAlexW4283746089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.