Evidence map›Paper›PMID 35778581›Full record

ArticlePflugers Archiv : European journal of physiology2022

Relaxin does not prevent development of hypoxia-induced pulmonary edema in rats.

Ute Kowalleck, Mohamed A Abdalla Ahmed, Julia Koedel, Katrin Schierle, Aida Salameh, Beate Rassler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Relaxin-when a successful super-drug is failing.Pflugers Archiv : European journal of physiology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ute KowalleckCarl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany.
Mohamed A Abdalla AhmedCarl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany.
Julia KoedelInstitute of Pathology, University of Leipzig, Leipzig, Germany.
Katrin SchierleInstitute of Pathology, University of Leipzig, Leipzig, Germany.
Aida SalamehDepartment of Pediatric Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany.
Beate RasslerCarl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany. Beate.Rassler@medizin.uni-leipzig.de.
Leipzig University · DELeipzig Heart Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute hypoxia impairs left ventricular (LV) inotropic function and induces development of pulmonary edema (PE). Enhanced and uneven hypoxic pulmonary vasoconstriction is an important pathogenic factor of hypoxic PE. We hypothesized that the potent vasodilator relaxin might reduce hypoxic pulmonary vasoconstriction and prevent PE formation. Furthermore, as relaxin has shown beneficial effects in acute heart failure, we expected that relaxin might also improve LV inotropic function in hypoxia. Forty-two rats were exposed over 24 h to normoxia or hypoxia (10% N

Indexed as

Pulmonary EdemaRelaxinAnimalsHypoxiaPneumoniaPulmonary ArteryRatsSaline SolutionVasodilator AgentsRelaxinSaline SolutionVasodilator AgentsCardiovascular functionNormobaric hypoxiaPulmonary edemaPulmonary inflammationRelaxin

Identifiers

PMID35778581
PMCPMC9492557
OpenAlexW4283782395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.