Evidence map›Paper›PMID 35778435›Full record

ArticleCommunications biology2022

Functional cargos of exosomes derived from Flk-1

Songying Cao, Yanqing Wu, E Albert Reece, Cheng Xu, Wei-Bin Shen, Sunjay Kaushal, Peixin Yang

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

  • Retraction · 2025-08-06Concerns/Issues about Data · Duplication of/in Image · Error in Data · Investigation by Company/Institution · Investigation by Third Party · Original Data and/or Images not Provided and/or not Available · Unreliable Data · Unreliable Results and/or Conclusions · · See also: https://pubpeer.com/publications/D8A133186F633A32BBF385253904CA
  • Retracted
5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Songying CaoDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Yanqing WuDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
E Albert ReeceDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Cheng XuDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Wei-Bin ShenDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Sunjay KaushalDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Peixin YangDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. pyang@som.umaryland.edu.ORCID http://orcid.org/0000-0002-2104-0699
University of Maryland, Baltimore · US

Funding

Apoptotic Mechanism of Maternal Diabetes-Induced Neural Tube DefectsR01DK083243 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI YANG, PEIXIN · 2010 to 2019
$3.1M
Autophagy and its Regulation in Diabetic EmbryopathyR01HD102206 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI YANG, PEIXIN · 2020 to 2024
$2.9M
Molecular Signalling Pathways and Cellular Stress in Diabetic EmbryopathyR01HD100195 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI REECE, E. ALBERT, YANG, PEIXIN · 2019 to 2023
$2.5M
Maternal Diabetes-Suppressed Vascular Signaling Induces Vasculopathy and Neural Tube DefectsR01HL131737 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI YANG, PEIXIN · 2016 to 2019
$2.1M
Molecular Signalling Pathways and Cellular Stress in Diabetic EmbryopathyR01DK103024 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI REECE, E. ALBERT, YANG, PEIXIN · 2014 to 2017
$1.7M
Autophagy and its Regulation in Diabetic EmbryopathyR01DK101972 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI YANG, PEIXIN · 2014 to 2017
$1.6M
NHLBI NIH HHS R01 HL131737NICHD NIH HHS R01 HD100195NICHD NIH HHS R01 HD102206NIDDK NIH HHS R01 DK083243NIDDK NIH HHS R01 DK101972NIDDK NIH HHS R01 DK103024
6 · The paper itself

Abstract

Various types of progenitors initiate individual organ formation and their crosstalk orchestrates morphogenesis for the entire embryo. Here we show that progenitor exosomal communication across embryonic organs occurs in normal development and is altered in embryos of diabetic pregnancy. Endoderm fibroblast growth factor 2 (FGF2) stimulates mesoderm Flk-1

Indexed as

Diabetes, GestationalExosomesNeural Tube DefectsFemaleFibroblast Growth Factor 2HumansNeurulationPregnancySurvivinFibroblast Growth Factor 2Survivin

Identifiers

PMID35778435
PMCPMC9249756
OpenAlexW4283747560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.