ArticleNature communications2022
Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages.The Journal of allergy and clinical immunology · 2026Article
- IL-9 Is Essential for ILC2-Mediated but Not Th2- and Th17-Cell-Mediated Allergic Airway Inflammation in Mice.European journal of immunology · 2026Article
- LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.Cancer discovery · 2026Article
- Macrophages in lung cancer: principal factors, regulatory mechanisms, and therapeutic opportunities: a narrative review.Translational lung cancer research · 2026Review
- Macrophage-intrinsic and IL-9-dependent arginine metabolism promotes lung tumor growth.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Recent perspectives on macrophage memory: types, mechanisms, and characteristics in pulmonary diseases.Cell communication and signaling : CCS · 2026Review
- Negative regulators antagonizing antitumor innate immune pathways in lung cancer immune evasion.Frontiers in immunology · 2026Review
- Molecular and spatial specialization of lung interstitial macrophage subsets: beyond chemokines.Frontiers in immunology · 2026Article
- Trem2 activation by renal tubular debris sustains Arg1Frontiers in immunology · 2026Article
- Review
- Article
- Single-cell transcriptomic analysis reveals the association of Ccl6+Ccr2+Arg1+ macrophages with renal interstitial fibrosis in AKI.PloS one · 2025Article
- The "double-edged sword" effect of cytokines in cancer: coexisting opportunities and challenges.Frontiers in immunology · 2025Review
- Association between inflammatory factors and melanoma: a bidirectional Mendelian randomization study.Cancer causes & control : CCC · 2024Article
- Function of alveolar macrophages in lung cancer microenvironment.Inflammation and regeneration · 2024Review
- The Role of Stroma in Cancer Metabolism.Cold Spring Harbor perspectives in medicine · 2024Review
- Regulation of macrophage activation by lactylation in lung disease.Frontiers in immunology · 2024Review
- Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma.Cell reports · 2023Article
- The World according to IL-9.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2023Review
Corrections and comments
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Authors and funding
27 authors at 9 institutions in 4 countries.
Yongyao FuDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Abigail PajulasDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0002-1137-1400
Jocelyn WangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0003-0016-3136
Baohua ZhouDepartment of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0003-1156-4517
Anthony CannonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Cherry Cheuk Lam CheungDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Jilu ZhangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Huaxin ZhouDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Amanda Jo FisherDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
David T OmsteadDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.
Sabrina KhanDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.ORCID 0000-0002-0531-897X
Lei HanDepartment of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Jean-Christophe RenauldLudwig Institute for Cancer Research, Experimental Medicine Unit, Université Catholique de Louvain, Brussels, 1200, Belgium.
Sophie PaczesnyDepartment of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC, 29425, USA.
Hongyu GaoDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0002-2699-626X
Lei YangDepartment of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Robert M TigheDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC, 27710, USA.ORCID 0000-0002-3465-9861
Paula Licona-LimónDepartamento de Biologia Celular y del Desarrollo, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico.
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, 06510, USA.ORCID 0000-0003-4461-0778
Shogo TakatsukaResearch Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Noda, Japan.
Daisuke KitamuraResearch Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Noda, Japan.ORCID 0000-0002-5195-0474
Jie SunDepartment of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0002-2347-4511
Basar BilgicerDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.
Catherine R SearsDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0002-5797-3458
Kai YangDepartment of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Mark H KaplanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mkaplan2@iupui.edu.ORCID 0000-0002-2923-8245
Indiana University School of MedicineUniversity of Notre Dame · USTokyo University of Science · JPDuke Medical Center · USLudwig Cancer Research · BEMayo Clinic in Arizona · USMedical University of South Carolina · USUniversidad Nacional Autónoma de México · MXYale University · US
Funding
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI June Bryan de la Pena · 2017 to 2026
$24.9MBASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASEST32HL007910 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Roland W. Herzog, Reuben Kapur · 1999 to 2026
$7.6MImmunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0MDual targeting of tumoral microenvironment and tumoral cells by blocking the IL-33/ST2 pathwayU01CA232491 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHEUNG, NAI-KONG V, PACZESNY, SOPHIE · 2018 to 2020
$4.3MTSLP in Th2 Immunity and Allergic Airway InflammationR01AI085046 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI ZHOU, BAOHUA · 2010 to 2019
$3.8MIL-33 induced-lL-9 producing type 2 innate lymphoid cells in the regulation of acute lung injury after hematopoietic stem cell transplantation (HSCT) in pediatric patientsR01HL158096 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PACZESNY, SOPHIE · 2022 to 2025
$2.3MTh9 cells in immediate hypersensitivityR01AI129241 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPLAN, MARK H · 2017 to 2021
$2.0MCharacterization of DNA repair in genomic and transcriptomic evolution of early lung carcinogenesisI01BX005353 · VA · RLR VA MEDICAL CENTER · PI SEARS, CATHERINE RUFATTO · 2021 to 2024
–BLRD VA I01 BX005353NCI NIH HHS U01 CA232491NHLBI NIH HHS R01 HL158096NHLBI NIH HHS T32 HL007910NIAID NIH HHS R01 AI085046NIAID NIH HHS R01 AI129241NIAID NIH HHS T32 AI060519NIGMS NIH HHS P20 GM121176
Abstract
Although IL-9 has potent anti-tumor activity in adoptive cell transfer therapy, some models suggest that it can promote tumor growth. Here, we show that IL-9 signaling is associated with poor outcomes in patients with various forms of lung cancer, and is required for lung tumor growth in multiple mouse models. CD4
Indexed as
Interleukin-9Lung NeoplasmsMacrophagesAnimalsCarcinogenesisMacrophages, AlveolarMiceIL9 protein, humanInterleukin-9
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.