ArticleJournal of advanced research2022
The role of mild and asymptomatic infections on COVID-19 vaccines performance: A modeling study.
Article in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Predictive models for health outcomes due to SARS-CoV-2, including the effect of vaccination: a systematic review.Systematic reviews · 2024Pooled it
- Mathematical models for dengue fever epidemiology: A 10-year systematic review.Physics of life reviews · 2022Pooled it
- Optimizing the sensitivity of detection of respiratory syncytial virus infections in longitudinal studies using the combination of weekly sample testing and biannual serology.American journal of epidemiology · 2026Article
- Impact of the first booster vaccine against SARS-CoV-2 in Chile.Infectious Disease Modelling · 2026Article
- Optimizing the sensitivity of detection of respiratory syncytial virus infections in longitudinal studies using the combination of weekly sample testing and biannual serology.medRxiv : the preprint server for health sciences · 2025Article
- The impact of non-pharmaceutical interventions on COVID-19 transmission and its effect on life expectancy in two European regions.BMC public health · 2025Article
- Modeling COVID-19 dynamics in the Basque Country: characterizing population immunity profile from 2020 to 2022.BMC infectious diseases · 2025Article
- Modelling COVID-19 mutant dynamics: understanding the interplay between viral evolution and disease transmission dynamics.Royal Society open science · 2024Article
- Impact of High Covid-19 Vaccination Rate in an Aging Population: Estimating Averted Hospitalizations and Deaths in the Basque Country, Spain Using Counterfactual Modeling.Journal of epidemiology and global health · 2024Article
- Cost-Effectiveness Analysis of Vaccines for COVID-19 According to Sex, Comorbidity and Socioeconomic Status: A Population Study.PharmacoEconomics · 2024Article
- COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine.Reports (MDPI) · 2023Review
- The effect of mixed vaccination rollout strategy: A modelling study.Infectious Disease Modelling · 2023Article
- Changes in Social and Clinical Determinants of COVID-19 Outcomes Achieved by the Vaccination Program: A Nationwide Cohort Study.International journal of environmental research and public health · 2022Article
- Modeling the initial phase of COVID-19 epidemic: The role of age and disease severity in the Basque Country, Spain.PloS one · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDifferent COVID-19 vaccine efficacies are reported, with remarkable effectiveness against severe disease. The so called sterilizing immunity, occurring when vaccinated individuals cannot transmit the virus, is still being evaluated. It is also unclear to what extent people with no symptoms or mild infection transmit the disease, and estimating their contribution to outbreaks is challenging.
objectiveWith an uneven roll out of vaccination, the purpose of this study is to investigate the role of mild and asymptomatic infections on COVID-19 vaccine performance as vaccine efficacy and vaccine coverage vary.
methodsWe use an epidemiological SHAR (Susceptible-Hospitalized-Asymptomatic-Recovered) model framework to evaluate the effects of vaccination in different epidemiological scenarios of coverage and efficacy. Two vaccination models, the vaccine V
resultsVaccine performance is driven by the ability of asymptomatic or mild disease cases transmitting the virus. Vaccines protecting against severe disease but failing to block transmission might not be able to reduce significantly the severe disease burden during the initial stage of a vaccination roll out programme, with an eventual increase on the number of overall infections in a population.
conclusionThe different COVID-19 vaccines currently in use have features placing them closer to one or the other of these two extreme cases, V
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.