ArticleJournal of advanced research2022
Salicylic acid fights against Fusarium wilt by inhibiting target of rapamycin signaling pathway in Fusarium oxysporum.
Article in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Optimizing prochloraz timing for curative control of Fusarium wilt in chili: a multi-target strategy targeting early root infection.Pest management science · 2026Article
- Differential Response of Banana Root Exudates and its Components on the Growth and Development of Banana Wilt Pathogen.Microbial ecology · 2026Article
- Comparative transcriptome analysis reveals key genes and signaling pathways mediated by salicylic acid in potato.BMC plant biology · 2025Article
- Article
- Grapevine Responses to the Entomopathogenic FungiMicroorganisms · 2025Article
- Mechanisms of regulated cell death during plant infection by the rice blast fungus Magnaporthe oryzae.Cell death and differentiation · 2025Review
- Salicylic acid induced by Bacillus megaterium causing systemic resistance against collar rot in Capsicum chinense.Plant cell reports · 2025Article
- Eco-friendly control of fusarium wilt in tomato: molecular docking and functional analysis of ZnO nanoparticles and biostimulants.Frontiers in plant science · 2025Article
- Extraction, analysis, and antifungal activity study of algae antibiotic active substances in plateau lakes.PloS one · 2025Article
- Fusarium Genome Sequencing and Assembly.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Beyond salt tolerance: SOS1-13's pivotal role in regulating the immune response toFrontiers in plant science · 2025Article
- Enhancing salicylic acid levels by its exogenous pretreatment to mitigate Fusarium oxysporum-induced biotic stress in Vigna mungo: defense pathways insights.Plant cell reports · 2024Article
- The TOR signalling pathway in fungal phytopathogens: A target for plant disease control.Molecular plant pathology · 2024Review
- The Ubiquitous Wilt-Inducing PathogenPathogens (Basel, Switzerland) · 2024Review
- Disruption of Cell Membranes and Redox Homeostasis as an Antibacterial Mechanism of Dielectric Barrier Discharge Plasma againstInternational journal of molecular sciences · 2024Article
- Antimicrobial Activities of Natural Bioactive Polyphenols.Pharmaceutics · 2024Review
- Inhibition of PotatoPlants (Basel, Switzerland) · 2024Article
- Editing Metabolism, Sex, and Microbiome: How Can We Help Poplar Resist Pathogens?International journal of molecular sciences · 2024Review
- Article
- Functional Analysis of a Salicylate Hydroxylase inJournal of fungi (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBiofungicides with low toxicity and high efficiency are a global priority for sustainable agricultural development. Phytohormone salicylic acid (SA) is an ancient medicine against various diseases in humans and activates the immune system in plants, but little is known of its function as a biofungicide.
objectivesHere, Fusarium oxysporum, the causal agent of devastating Fusarium wilt and immunodepressed patients, was used as a model system to explore whether SA can enter the pathogen cells and suppress key targets of the pathogen.
methodsOxford Nanopore MinION sequencing and high-throughput chromosome conformation capture (Hi-C) sequencing were used to analyzed the genome of F. oxysporum. In addition, RNA-seq, qRT-PCR, and western blotting were conducted to detect gene and protein expression levels.
resultsWe isolated and sequenced the genome of F. oxysporum from potato dry rot, and the F. oxysporum included 12 chromosomes and 52.3 Mb genomic length. Pharmacological assays showed that exogenous application of SA can efficiently arrest hyphal growth, spore production, and pathogenicity of F. oxysporum, whereas endogenous salicylate hydroxylases significantly detoxify SA. The synergistic growth inhibition of F. oxysporum was observed when SA was combined with rapamycin. Kinase assays showed that SA inhibits FoTOR complex 1 (FoTORC1) by activating FoSNF1 in vivo. Transgenic potato plants with the interference of FoTOR1 and FoSAH1 genes inhibited the invasive growth of hyphae and significantly prevented the occurrence of Fusarium wilt.
conclusionThis study revealed the underlying mechanisms of SA against F. oxysporum and provided insights into SA in controlling various fungal diseases by targeting the SNF1-TORC1 pathway of pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.