Evidence map›Paper›PMID 35777869›Full record

ArticleBMJ open2022

Identifying the top research priorities in medically not yet explained symptoms (MNYES): a James Lind Alliance priority setting partnership.

Christina Maria van der Feltz-Cornelis, Jennifer Sweetman, Mark Edwards, Nicholas Gall, Jennifer Gilligan, Stephanie Hayle, Arvind Kaul, Andrew Stephen Moriarty, Petros Perros, James Sampford and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Medically not yet explained symptoms in hypothyroidism.Nature reviews. Endocrinology · 2024
    Review
  7. Effect of physical activity on long COVID fatigue: an unsolved enigma.European journal of translational myology · 2023
    Article
  8. Integrated care pathways: a new approach for integrated care systems.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christina Maria van der Feltz-CornelisDepartment of Health Sciences, University of York, York, UK christina.vanderfeltz-cornelis@york.ac.uk.ORCID 0000-0001-6925-8956
Jennifer SweetmanDepartment of Health Sciences, University of York, York, UK.ORCID 0000-0003-1969-4586
Mark EdwardsSt George's University of London, London, UK.
Nicholas GallDepartment of Cardiology, University of London Kings College Hospital, London, UK.
Jennifer GilliganLiaison team, Tees Esk and Wear Valleys Foundation Trust, York, UK.
Stephanie HaylePatient Representative, North Yorkshire, UK.
Arvind KaulSt George's University of London, London, UK.
Andrew Stephen MoriartyDepartment of Health Sciences, University of York, York, UK.ORCID 0000-0003-0770-3262
Petros PerrosDepartment of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
James SampfordLiaison team, Tees Esk and Wear Valleys Foundation Trust, York, UK.
Natalie SmithDepartment of Health Sciences, University of York, York, UK.
Iman ElfeddaliTranzo Department, Tilburg University, Tilburg, Netherlands.
Danielle VarleyDepartment of Health Sciences, University of York, York, UK.
Jonathan GowerJames Lind Alliance, Southampton, UK.

Funding

Wellcome Trust 204829
6 · The paper itself

Abstract

objectivesThis study establishes research priorities for medically not yet explained symptoms (MNYES), also known as persistent physical symptoms or medically unexplained symptoms, from the perspective of patients, caregivers and clinicians, in a priority setting partnership (PSP) following the James Lind Alliance (JLA) approach. Research into such symptoms in general has been poorly funded over the years and so far has been primarily researcher-led with minimal input from patients, caregivers and clinicians; and sometimes has been controversial.

designJLA PSP method. The PSP termed these symptoms MNYES.

methodsThe study was conducted according to the JLA's detailed methodology for conducting priority setting exercises. It involved five key stages: defining the appropriate term for the conditions under study by the PSP Steering Group; gathering questions on MNYES from patients, caregivers and clinicians in a publicly accessible survey; checking these research questions against existing evidence; interim prioritisation in a second survey; and a final multi-stakeholder consensus meeting to determine the top 10 unanswered research questions using the modified nominal group methodology.

resultsOver 700 responses from UK patients, caregivers and clinicians were identified in the two surveys and charities contributed from a broad range of medical specialties and primary care. The final top 10 unanswered research questions cover, among others: treatment strategies, personalisation of treatment, collaborative care pathways, training for clinicians and outcomes that matter to patients.

interpretationThe top 10 unanswered research questions are expected to generate much needed, relevant and impactful research into MNYES.

Indexed as

CaregiversResearch DesignConsensusHumansResearch PersonnelSurveys and QuestionnairesAdult cardiologyAdult neurologyAdult psychiatryFunctional bowel disordersPRIMARY CARERheumatology

Identifiers

PMID35777869
PMCPMC9252198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.