Observational studyThe Journal of rheumatology2022
Physical Activity Associates With Lower Systemic Inflammatory Gene Expression in Rheumatoid Arthritis.
Observational study in The Journal of rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Physical Activity for Human and Planetary Health: Incorporating Green Exercise in the Management of Rheumatic Disease.Rheumatic diseases clinics of North America · 2026Review
- The Type I Interferon Axis in Systemic Autoimmune Diseases: From Molecular Pathways to Targeted Therapy.Biomolecules · 2025Review
- [Association of Rest-Activity Rhythm With the Risk of Rheumatoid Arthritis and Effect Modification by Genetic Susceptibility].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia.Advances in rheumatology (London, England) · 2025Article
- Differential Gene Expression in Rheumatoid Arthritis: Implication in the Diagnosis and Individualized Treatment Plan.Journal of biotechnology and biomedicine · 2025Article
- Distinct NK cell function and gene expression in children with acute lymphoblastic leukemia in remission before and after acute exercise: an exploratory study.Frontiers in immunology · 2025Article
- Rheumatoid arthritis treatment: Is exercise a game changer?Turkish journal of physical medicine and rehabilitation · 2024Review
- Sleep patterns, physical activity, genetic susceptibility, and incident rheumatoid arthritis: a prospective cohort study.BMC medicine · 2024Article
- Complex rehabilitation of patients with rheumatoid arthritis.Rheumatology international · 2024Article
- Role of IFN-α in Rheumatoid Arthritis.Current rheumatology reports · 2024Review
- Correlation between Physical Activity and Depression in Community-Dwelling Older Adult Palestinians.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- Chronic rheumatologic disorders and cardiovascular disease risk in women.American heart journal plus : cardiology research and practice · 2023Review
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Authors and funding
9 authors.
Funding
Abstract
objectiveWhile general population studies have shown inverse associations between physical activity and common inflammatory biomarkers, the effects of physical activity on inflammatory gene expression and signaling pathways in rheumatoid arthritis (RA) remain unknown. We aimed to determine whether physical activity independently associates with expression of inflammatory genes among people with RA.
methodsThis was a prospective observational study of adults with RA. Physical activity was measured by quantitative actigraphy over 7 consecutive days, and peripheral blood collected during the same time period was used for RNA sequencing followed by differential gene expression, pathway, and network analyses.
resultsActigraphy and RNA sequencing data were evaluated in 35 patients. The cohort had a mean age of 56 (SD 12) years, and was 91% female, 31% White, 9% Black, 9% Asian, and 40% Hispanic. We found 767 genes differentially expressed (adjusted
conclusionPatients with RA who were more physically active had lower expression of immune signaling pathways implicated in RA pathogenesis, even after adjusting for disease activity, suggesting that physical activity may confer a protective effect in RA.
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