Evidence map›Paper›PMID 35777776›Full record

ArticleThe European respiratory journal2023

Associations of hiatus hernia with CT-based interstitial lung changes: the MESA Lung Study.

John S Kim, Jinhye Kim, Xiaorui Yin, Grant T Hiura, Michaela R Anderson, Eric A Hoffman, Ganesh Raghu, Imre Noth, Ani Manichaikul, Stephen S Rich and 6 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05716022 (Hiatal Hernia and Pulmonary Involvement Related to Subclinical Lung Injury and Fibrosis), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05716022 completednot on this map

Hiatal Hernia and Pulmonary Involvement Related to Subclinical Lung Injury and Fibrosis

TypeobservationalSponsorUniversity of VirginiaRan2023 to 2025Enrolled14ConditionsHiatal Hernia, Interstitial Lung DiseaseArmsBlood Collection, Bronchoscopy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Reply to WardAmerican journal of respiratory and critical care medicine · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

John S KimDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA jk6jb@virginia.edu.
Jinhye KimDepartment of Radiology, Weill Cornell Medical College, New York, NY, USA.
Xiaorui YinDepartment of Radiology, Weill Cornell Medical College, New York, NY, USA.
Grant T HiuraDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-5135-4309
Michaela R AndersonDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eric A HoffmanDepartment of Radiology, Carver School of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-8456-9437
Ganesh RaghuDepartment of Medicine, University of Washington, Seattle, WA, USA.
Imre NothDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ani ManichaikulCenter for Public Health Genomics and Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Stephen S RichCenter for Public Health Genomics and Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Benjamin M SmithDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Anna J PodolanczukDivision of Pulmonary and Critical Care, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-9559-1485
Christine Kim GarciaDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
R Graham BarrDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Martin R PrinceDepartment of Radiology, Weill Cornell Medical College, New York, NY, USA.
Elizabeth C OelsnerDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Columbia University Irving Medical Center · USCornell University · USUniversity of Virginia · USWestchester Medical Center · USUniversity of Iowa · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Subclinical Interstitial Lung Disease in MESA and FAR-ILDR01HL103676 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GARCIA, CHRISTINE KIM · 2011 to 2020
$6.4M
Chronic obstructive pulmonary disease in non-smokersR01HL130506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERBSTMAN, JULIE BETH, SMITH, BENJAMIN M. · 2016 to 2025
$6.3M
Architectural structure and regulation of TOLLIP in IPFR01HL130796 · NHLBI · UNIVERSITY OF VIRGINIA · PI NOTH, IMRE · 2016 to 2019
$3.1M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K23 HL130627NHLBI NIH HHS K23 HL140199NHLBI NIH HHS K23 HL150301NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL103676NHLBI NIH HHS R01 HL130506NHLBI NIH HHS R01 HL130796NHLBI NIH HHS RC1 HL100543NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

backgroundHiatus hernia (HH) is prevalent in adults with pulmonary fibrosis. We hypothesised that HH would be associated with markers of lung inflammation and fibrosis among community-dwelling adults and stronger among

methodsIn the Multi-Ethnic Study of Atherosclerosis, HH was assessed from cardiac and full-lung computed tomography (CT) scans performed at Exam 1 (2000-2002, n=3342) and Exam 5 (2010-2012, n=3091), respectively. Percentage of high attenuation areas (HAAs; percentage of voxels with attenuation between -600 and -250 HU) was measured from cardiac and lung scans. Interstitial lung abnormalities (ILAs) were examined from Exam 5 scans (n=2380). Regression models were used to examine the associations of HH with HAAs, ILAs and serum matrix metalloproteinase-7 (MMP-7), and adjusted for age, sex, race/ethnicity, educational attainment, smoking, height, weight and scanner parameters for HAA analysis.

resultsHH detected from Exam 5 scans was associated with a mean percentage difference in HAAs of 2.23% (95% CI 0.57-3.93%) and an increase of 0.48% (95% CI 0.07-0.89%) per year, particularly in

conclusionsHH was associated with more HAAs over time, particularly among

Indexed as

Hernia, HiatalLung Diseases, InterstitialAdultHumansLungMatrix Metalloproteinase 7Tomography, X-Ray ComputedMatrix Metalloproteinase 7

Identifiers

PMID35777776
PMCPMC10203882
OpenAlexW4283780073

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.