Evidence map›Paper›PMID 35777775›Full record

ArticleThe European respiratory journal2022

Participation in community-based lung cancer screening: the Yorkshire Lung Screening Trial.

Philip A J Crosbie, Rhian Gabe, Irene Simmonds, Neil Hancock, Panos Alexandris, Martyn Kennedy, Suzanne Rogerson, David Baldwin, Richard Booton, Claire Bradley and 13 more

Abstract read
In one paragraph

Article in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Mobile Cancer Screening Programs: A Systematic Review of Implementation Challenges and Population Access.International journal of environmental research and public health · 2026
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Low dose CT for lung cancer screening.Journal of thoracic disease · 2025
    Article
  12. Article
  13. Article
  14. Updates in Lung Cancer Screening: A Decade of Evidence.Seminars in respiratory and critical care medicine · 2025
    Review
  15. Patients' Attitude toward Less Frequent Surveillance of Low-Risk Pancreatic Cysts: A Multicenter European Cohort Study.Medical decision making : an international journal of the Society for Medical Decision Making · 2025
    Observational
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Philip A J CrosbieDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.
Rhian GabeCentre for Cancer Prevention, Queen Mary University of London, London, UK.ORCID 0000-0002-0273-3094
Irene SimmondsInstitute of Health Sciences, University of Leeds, Leeds, UK.
Neil HancockInstitute of Health Sciences, University of Leeds, Leeds, UK.ORCID 0000-0002-1768-2971
Panos AlexandrisCentre for Cancer Prevention, Queen Mary University of London, London, UK.ORCID 0000-0002-4489-0282
Martyn KennedyLeeds Teaching Hospitals NHS Trust, Leeds, UK.
Suzanne RogersonLeeds Teaching Hospitals NHS Trust, Leeds, UK.
David BaldwinDept of Respiratory Medicine, Nottingham University Hospitals, Nottingham, UK.
Richard BootonDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.ORCID 0000-0003-4512-2899
Claire BradleyCraigavon Area Hospital, Southern Health and Social Care Trust, Portadown, UK.
Mike DarbyLeeds Teaching Hospitals NHS Trust, Leeds, UK.
Claire EckertInstitute of Health Sciences, University of Leeds, Leeds, UK.
Kevin N FranksInstitute of Health Sciences, University of Leeds, Leeds, UK.ORCID 0000-0001-9468-7947
Jason LindopLeeds Teaching Hospitals NHS Trust, Leeds, UK.
Sam M JanesLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID 0000-0002-6634-5939
Henrik MøllerThe Danish Clinical Quality Program and Clinical Registries (RKKP), Aarhus, Denmark.
Rachael L MurrayLifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
Richard D NealCollege of Medicine and Health, University of Exeter, Exeter, UK.
Samantha L QuaifeWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID 0000-0002-4918-6382
Sara UppertonLeeds Teaching Hospitals NHS Trust, Leeds, UK.
Bethany ShinkinsInstitute of Health Sciences, University of Leeds, Leeds, UK.
Puvan TharmanathanYork Trials Unit, York, UK.
Matthew E J CallisterInstitute of Health Sciences, University of Leeds, Leeds, UK matthew.callister@nhs.net.ORCID 0000-0001-8157-0803

Funding

Cancer Research UK 24460
6 · The paper itself

Abstract

backgroundScreening with low-dose computed tomography (LDCT) reduces lung cancer mortality; however, the most effective strategy for optimising participation is unknown. Here we present data from the Yorkshire Lung Screening Trial, including response to invitation, screening eligibility and uptake of community-based LDCT screening.

methodsIndividuals aged 55-80 years, identified from primary care records as having ever smoked, were randomised prior to consent to invitation to telephone lung cancer risk assessment or usual care. The invitation strategy included general practitioner endorsement, pre-invitation and two reminder invitations. After telephone triage, those at higher risk were invited to a Lung Health Check (LHC) with immediate access to a mobile CT scanner.

resultsOf 44 943 individuals invited, 50.8% (n=22 815) responded and underwent telephone-based risk assessment (16.7% and 7.3% following first and second reminders, respectively). A lower response rate was associated with current smoking status (adjusted OR 0.44, 95% CI 0.42-0.46) and socioeconomic deprivation (adjusted OR 0.58, 95% CI 0.54-0.62 for the most

conclusionsTelephone risk assessment followed by a community-based LHC is an effective strategy for lung cancer screening implementation. However, lower participation associated with current smoking status and socioeconomic deprivation underlines the importance of research to ensure equitable access to screening.

Indexed as

Early Detection of CancerLung NeoplasmsHumansLungMass ScreeningTomography, X-Ray Computed

Identifiers

PMID35777775
PMCPMC9684623

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.