Evidence map›Paper›PMID 35777773›Full record

Trial reportThe European respiratory journal2022

Effect of asthma management with exhaled nitric oxide

Vanessa E Murphy, Megan E Jensen, Elizabeth G Holliday, Warwick B Giles, Helen L Barrett, Leonie K Callaway, Andrew Bisits, Michael J Peek, Sean K Seeho, Alistair Abbott and 8 more

Open access · bronzeAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Asthma Control During Pregnancy and Adverse Perinatal Outcomes: A Systematic Review.The Australian & New Zealand journal of obstetrics & gynaecology · 2026
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Early Gestational Wildfire-Related PMInternational journal of environmental research and public health · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Treatable Traits in Pregnant Women with Asthma.Respiration; international review of thoracic diseases · 2024
    Review
  12. Treatable traits in asthma during pregnancy: a call for a shift towards a precision-based management approach.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Vanessa E MurphyPriority Research Centre Grow Up Well, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia vanessa.murphy@newcastle.edu.au.ORCID https://orcid.org/0000-0003-3282-1324
Megan E JensenPriority Research Centre Grow Up Well, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia.
Elizabeth G HollidaySchool of Medicine and Public Health, Faculty of Health, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia.
Warwick B GilesSpecialty of Obstetrics, Gynaecology and Neonatology, Sydney Medical School Northern, University of Sydney, Sydney, Australia.
Helen L BarrettQueensland Diabetes and Endocrine Centre, Mater Health Services, South Brisbane, Australia.
Leonie K CallawaySchool of Medicine, University of Queensland, Brisbane, Australia.
Andrew BisitsBirthing Unit, Royal Hospital for Women Randwick, Randwick, Australia.
Michael J PeekAustralian National University Medical School, The Australian National University, Canberra, Australia.
Sean K SeehoSpecialty of Obstetrics, Gynaecology and Neonatology, Sydney Medical School Northern, University of Sydney, Sydney, Australia.
Alistair AbbottNepean Hospital, Kingswood, Australia.
Annelies L RobijnPriority Research Centre Grow Up Well, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia.
Paul B ColditzPerinatal Research Centre, UQCCR, University of Queensland, Brisbane, Australia.
Andrew SearlesHunter Medical Research Institute, Newcastle, Australia.
John AttiaSchool of Medicine and Public Health, Faculty of Health, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia.ORCID https://orcid.org/0000-0001-9800-1308
Kirsten McCafferySchool of Public Health, University of Sydney, Sydney, Australia.
Michael J HensleyDepartment of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia.
Joerg MattesPriority Research Centre Grow Up Well, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia.
Peter G GibsonDepartment of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia.ORCID https://orcid.org/0000-0001-5865-489X
Hunter Medical Research Institute · AUThe University of Sydney · AUJohn Hunter Hospital · AUThe University of Queensland · AUAustralian National University · AUMater Health Services · AUNepean Hospital · AURoyal Hospital for Women · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAsthma exacerbations in pregnancy are associated with adverse perinatal outcomes. We aimed to determine whether fractional exhaled nitric oxide (

methodsThe Breathing for Life Trial was a multicentre, parallel-group, randomised controlled trial conducted in six hospital antenatal clinics, which compared asthma management guided by

resultsPregnant women with current asthma were recruited; 599 to the control group (608 infants) and 601 to the intervention (615 infants). There were no significant group differences for the primary composite perinatal outcome (152 (25.6%) out of 594 control, 177 (29.4%) out of 603 intervention; OR 1.21, 95% CI 0.94-1.56; p=0.15), preterm birth (OR 1.14, 95% CI 0.78-1.68), SGA (OR 1.06, 95% CI 0.78-1.68), perinatal mortality (OR 3.62, 95% CI 0.80-16.5), neonatal hospitalisation (OR 1.24, 95% CI 0.89-1.72) or maternal asthma exacerbations requiring hospital admission or emergency department presentation (OR 1.19, 95% CI 0.69-2.05).

conclusion

Indexed as

AsthmaPremature BirthExhalationFemaleHumansInfantInfant, NewbornNitric OxidePregnancyRespirationNitric Oxide

Identifiers

PMID35777773
PMCPMC9669403
OpenAlexW4283771084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.