Evidence map›Paper›PMID 35777728›Full record

ReviewPractical radiation oncology

One Year of Clinic-Wide Cherenkov Imaging for Discovery of Quality Improvement Opportunities in Radiation Therapy.

Daniel A Alexander, Savannah M Decker, Michael Jermyn, Petr Bruza, Rongxiao Zhang, Erli Chen, Tatum L McGlynn, Rory A Rosselot, Jae Lee, Melanie L Rose and 4 more

Abstract readReview
In one paragraph

Review in Practical radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Assessment of Linac photon dose delivery on Cherenkov production.Physics and imaging in radiation oncology · 2026
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  10. Optical (Cherenkov) dosimetry to unravel the radiobiological effects of radioisotope based therapy.European journal of nuclear medicine and molecular imaging · 2025
    Article
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  12. Hybrid Monte Carlo model for efficient tissue Cherenkov emission estimation to assess changes from beam size, energy and incidence.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel A AlexanderThayer School of Engineering, Dartmouth College, Hanover, New Hampshire. Electronic address: daniel.alexander1@pennmedicine.upenn.edu.
Savannah M DeckerThayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Dose Optics LLC, Lebanon, New Hampshire.
Michael JermynThayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Dose Optics LLC, Lebanon, New Hampshire.
Petr BruzaThayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Dose Optics LLC, Lebanon, New Hampshire.
Rongxiao ZhangThayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire; Dartmouth Cancer Center, Lebanon, New Hampshire.
Erli ChenCheshire Medical Center, Keene, New Hampshire.
Tatum L McGlynnDartmouth Cancer Center, Lebanon, New Hampshire.
Rory A RosselotDartmouth Cancer Center, Lebanon, New Hampshire.
Jae LeeDartmouth Cancer Center, Lebanon, New Hampshire.
Melanie L RoseDartmouth Cancer Center, Lebanon, New Hampshire.
Benjamin B WilliamsThayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire; Dartmouth Cancer Center, Lebanon, New Hampshire.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Dose Optics LLC, Lebanon, New Hampshire; Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
David J GladstoneThayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
Lesley A JarvisGeisel School of Medicine, Dartmouth College, Hanover, New Hampshire; Dartmouth Cancer Center, Lebanon, New Hampshire.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
DoseRT™ : A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy VerificationR44CA232879 · NCI · DOSEOPTICS, LLC · PI William Ware · 2018 to 2026
$5.2M
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPYR01EB023909 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI GLADSTONE, DAVID J., JARVIS, LESLEY A · 2017 to 2024
$4.4M
NCI NIH HHS P30 CA023108NCI NIH HHS R44 CA232879NIBIB NIH HHS R01 EB023909
6 · The paper itself

Abstract

purposeCherenkov imaging is clinically available as a radiation therapy treatment verification tool. The aim of this work was to discover the benefits of always-on Cherenkov imaging as a novel incident detection and quality improvement system through review of all imaging at our center. METHODS AND MATERIALS: Multicamera Cherenkov imaging systems were permanently installed in 3 treatment bunkers, imaging continuously over a year. Images were acquired as part of normal treatment procedures and reviewed for potential treatment delivery anomalies.

resultsIn total, 622 unique patients were evaluated for this study. We identified 9 patients with treatment anomalies occurring over their course of treatment, which were only detected with Cherenkov imaging. Categorizing each event indicated issues arising in simulation, planning, pretreatment review, and treatment delivery, and none of the incidents were detected before this review by conventional measures. The incidents identified in this study included dose to unintended areas in planning, dose to unintended areas due to positioning at treatment, and nonideal bolus placement during setup.

conclusionsCherenkov imaging was shown to provide a unique method of detecting radiation therapy incidents that would have otherwise gone undetected. Although none of the events detected in this study reached the threshold of reporting, they identified opportunities for practice improvement and demonstrated added value of Cherenkov imaging in quality assurance programs.

Indexed as

Quality ImprovementComputer SimulationHumans

Identifiers

PMID35777728
PMCPMC10984217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.