ArticleMagnetic resonance imaging2022
Quantification of lung ventilation defects on hyperpolarized MRI: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD study.
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Article in Magnetic resonance imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Comparison of phase-resolved functional lung (PREFUL) MRI and CT parametric response mapping (PRM) in COSYCONET COPD.European radiology · 2026Article
- Benchmarking Hybrid CNN-Transformer Versus Pure Transformer Architectures for Accelerated HyperpolarizedJournal of magnetic resonance imaging : JMRI · 2026Article
- Robust Segmentation of Lung Proton and Hyperpolarized Gas MRI with Vision Transformers and CNNs: A Comparative Analysis of Performance Under Artificial Noise.Bioengineering (Basel, Switzerland) · 2025Article
- Platelet activation and COPD-related clinical and imaging characteristics: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study.Respiratory medicine · 2025Article
- MRI-assessed Dynamic Hyperinflation Induced by Tachypnea in Chronic Obstructive Pulmonary Disease: The SPIROMICS-HF Study.Radiology. Cardiothoracic imaging · 2025Observational
- Quantifying heterogeneity in an animal model of acute respiratory distress syndrome, a comparison of inspired sinewave technique to computed tomography.Scientific reports · 2024Article
- Deep Learning Approaches for Quantifying Ventilation Defects in Hyperpolarized Gas Magnetic Resonance Imaging of the Lung: A Review.Bioengineering (Basel, Switzerland) · 2023Review
- Mapping Alveolar Oxygen Partial Pressure in COPD Using Hyperpolarized Helium-3: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study.Tomography (Ann Arbor, Mich.) · 2022Article
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Authors and funding
15 authors at 9 institutions in 3 countries.
Xuzhe ZhangDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Elsa D AngeliniDepartment of Biomedical Engineering, Columbia University, New York, NY, USA; NIHR Imperial BRC, ITMAT Data Science Group, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.
Fateme S HaghpanahDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Andrew F LaineDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Yanping SunDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Grant T HiuraDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Stephen M DashnawDepartment of Radiology, Columbia University Irving Medical Center, New York, NY, USA.
Martin R PrinceDepartment of Radiology, Columbia University Irving Medical Center, New York, NY, USA; Department of Radiology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, IA, USA; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA; Department of Medicine, University of Iowa, Iowa City, IA, USA.
Bharath Ambale-VenkateshSchool of Medicine, John Hopkins University, Baltimore, MD, USA.
Joao A LimaSchool of Medicine, John Hopkins University, Baltimore, MD, USA.
Jim M WildPOLARIS, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Emlyn W HughesDepartment of Physics, Columbia University, New York, NY, USA.
R Graham BarrDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA; Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.
Wei ShenDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Columbia University Irving Medical Center, New York, NY, USA; Institute of Human Nutrition, Columbia University Irving Medical Center, New York, NY, USA; Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY, USA. Electronic address: ws2003@columbia.com.
Columbia University · USColumbia University Irving Medical Center · USCornell University · USJohns Hopkins Medicine · USJohns Hopkins University · USResonance Research (United States) · USUniversity of Iowa · USUniversity of Sheffield · GBUniversity of Toronto · CA
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MRESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MNovel Quantitative Emphysema Subtypes in MESA and SPIROMICSR01HL121270 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARR, R GRAHAM, LAINE, ANDREW FRANCIS · 2014 to 2022
$5.6MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MTO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8MBritish Heart Foundation SP/14/6/31350Medical Research Council MR/M008894/1NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL121270NIDDK NIH HHS P30 DK026687
Abstract
purposeTo develop an end-to-end deep learning (DL) framework to segment ventilation defects on pulmonary hyperpolarized MRI. MATERIALS AND
methodsThe Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease (COPD) study is a nested longitudinal case-control study in older smokers. Between February 2016 and July 2017, 56 participants (age, mean ± SD, 74 ± 8 years; 34 men) underwent same breath-hold proton (
resultsConventional-DA improved
conclusionThe proposed cascaded U-Net framework generated fully-automated segmentation of ventilation defects on
Indexed as
AtherosclerosisPulmonary Disease, Chronic ObstructiveAgedAged, 80 and overCase-Control StudiesHeliumHumansLungMagnetic Resonance ImagingMaleProtonsRetrospective StudiesHeliumProtonsCOPDDeep learningHyperpolarized gasMRIVentilation defects
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.