SynthesisNeuroscience and biobehavioral reviews2022
Insulin resistance in depression: A large meta-analysis of metabolic parameters and variation.
Synthesis in Neuroscience and biobehavioral reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Investigating the functional connectivity between central glucagon-like peptide-1 (GLP-1) and glutamatergic signaling: a systematic review.CNS spectrums · 2026Pooled it
- Effects of the selective serotonin reuptake inhibitors citalopram and escitalopram on glucolipid metabolism: a systematic review.Frontiers in endocrinology · 2025Pooled it
- Efficacy of empagliflozin as adjunctive therapy to citalopram in major depressive disorder: a randomized double-blind, placebo-controlled clinical trial.BMC psychiatry · 2024Trial
- Suicide mortality in metabolic dysfunction-associated liver diseases: a nationwide cohort study.Annals of medicine · 2026Article
- High plasma levels of soluble triggering receptor expressed on Myeloid Cells 2 were associated with depression in patients with newly diagnosed type 2 diabetes mellitus.Journal of clinical & translational endocrinology · 2026Article
- Sleep quality partially mediates the association between remnant cholesterol inflammatory index and depressive symptoms: multi-cohort analysis from cross-sectional and longitudinal cohorts.European archives of psychiatry and clinical neuroscience · 2026Article
- Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs.The international journal of neuropsychopharmacology · 2026Article
- The Gut Microbiota-Astrocyte Axis: New Insights into the Mechanisms of Comorbid Major Depressive Disorder in Type 2 Diabetes Mellitus.Molecular neurobiology · 2026Review
- Review
- Triglyceride-glucose waist-to-height ratio improves risk stratification for depressive symptoms: evidence from NHANES.European archives of psychiatry and clinical neuroscience · 2026Article
- Depression trajectory modifies the association between estimated glucose disposal rate and incident stroke: a prospective cohort study.BMC cardiovascular disorders · 2026Article
- Associations of plasma biomarkers of Alzheimer's disease pathology with modifiable risk factors and cognitive and functional outcomes: evidence from cross-sectional prediction and latent path analyses in the Bio-Hermes-001 cohort.Alzheimer's research & therapy · 2026Article
- Blunted anticipation, but not consummation, of food rewards in depression.Cell reports. Medicine · 2026Article
- Metabolic hormone and adipokine alterations in major depressive disorder in relation to the acute-phase inflammatory response and early-life adversity.Communications medicine · 2026Article
- Depressive and Anxiety Symptoms in Women with Polycystic Ovary Syndrome: A Meta-Analysis.Journal of clinical medicine · 2026Review
- Lower insulin resistance in Chinese patients with severe major depressive disorder: associations with the inflammatory response.BMC psychiatry · 2026Article
- Association between glycemic control, mental problems and nutrition in individuals with type 1 and type 2 diabetes mellitus in primary care settings.BMC public health · 2026Article
- Triglyceride-glucose index, genetic predisposition, and incident depression: a prospective cohort study from the UK Biobank.Psychological medicine · 2026Article
- Immunometabolic blood biomarkers of developmental trajectories of depressive symptoms: findings from the ALSPAC birth cohort.Molecular psychiatry · 2026Article
- The effectiveness of high-intensity interval training (HIIT) in adults with psychiatric disorders: a scoping review.Social psychiatry and psychiatric epidemiology · 2026Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Increased insulin resistance is recognized in psychiatric disorders, such as schizophrenia and bipolar disorder, but its occurrence in depression is less clear. Our aims were to verify if insulin resistance is altered in depression, to test the metabolic subgroup hypothesis of depression and if there are changes with antidepressants. Inclusion criteria were studies including adult subjects with depression and either a control group or follow-up after treatment with antidepressants, and assessing fasting insulin or glucose levels or the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index. Seventy studies with 240,704 participants were included. Both insulin levels and the HOMA-IR index were increased in acute depression. Neither insulin nor the HOMA-IR index were altered during remission. Insulin was increased in atypical, but not typical depression. There was higher variation in insulin in individuals with depression than in controls. Insulin resistance did not change with antidepressant treatment. Insulin resistance is increased in depression during acute episodes. Heterogeneity was high in most of the analyses. Laboratory assessment of insulin resistance might have clinical utility in people with depression for diagnosis of the metabolic subtype and treatment selection, following precision psychiatry standards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.