Evidence map›Paper›PMID 35777467›Full record

ArticleJournal of molecular biology2022

Solution Structural Studies of Pre-amyloid Oligomer States of the Biofilm Protein Aap.

Alexander E Yarawsky, Jesse B Hopkins, Leonie Chatzimagas, Jochen S Hub, Andrew B Herr

Abstract read
In one paragraph

Article in Journal of molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander E YarawskyDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jesse B HopkinsThe Biophysics Collaborative Access Team (BioCAT), Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL, USA.
Leonie ChatzimagasTheoretical Physics and Center for Biophysics, Saarland University, Saarbrücken, Germany.
Jochen S HubTheoretical Physics and Center for Biophysics, Saarland University, Saarbrücken, Germany.
Andrew B HerrDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: Andrew.Herr@cchmc.org.

Funding

The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
Time resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9M
STUDIES OF METAL-DEPENDENT INTERCELLULAR ADHESION IN STAPHYLOCOCCAL BIOFILMSR01GM094363 · NIGMS · UNIVERSITY OF CINCINNATI · PI HERR, ANDREW B · 2011 to 2021
$2.5M
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
NIGMS NIH HHS P30 GM138395NIGMS NIH HHS P41 GM103622NIGMS NIH HHS R01 GM094363NIH HHS S10 OD018090
6 · The paper itself

Abstract

Staphylococcus epidermidis is a commensal bacterium on human skin that is also the leading cause of medical device-related infections. The accumulation-associated protein (Aap) from S. epidermidis is a critical factor for infection via its ability to mediate biofilm formation. The B-repeat superdomain of Aap is composed of 5 to 17 Zn

Indexed as

AmyloidBacterial ProteinsBiofilmsStaphylococcus epidermidisHumansModels, ChemicalMutationProtein MultimerizationScattering, Small AngleX-Ray DiffractionAmyloidBacterial Proteinsanalytical ultracentrifugationcircular dichroismequilibriumprotein flexibilitySAXS

Identifiers

PMID35777467
PMCPMC9615840

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.