Evidence map›Paper›PMID 35777457›Full record

ArticleJournal of biotechnology2022

High yield secretion of human erythropoietin from tobacco cells for ex vivo differentiation of hematopoietic stem cells towards red blood cells.

Uddhab Karki, Tristen Wright, Jianfeng Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Uddhab KarkiArkansas Biosciences Institute, USA; Department of Biological Sciences, USA.
Tristen WrightDepartment of Biological Sciences, USA.
Jianfeng XuArkansas Biosciences Institute, USA; College of Agriculture, Arkansas State University, Jonesboro, AR 72401, USA. Electronic address: jxu@astate.edu.
Arkansas Biosciences Institute · USArkansas State University · US

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett · 2012 to 2026
$60.9M
Engineering novel designer biologics in plant cells for oral treatment of ulcerative colitisR15DK128757 · NIDDK · ARKANSAS STATE UNIVERSITY · PI XU, JIANFENG · 2021 to 2021
$395k
A Novel Plant Cell Bio-Production Platform for Therapeutic ProteinsR43GM093621 · NIGMS · BIOSTRATEGIES, LC · PI RADIN, DAVID, XU, JIANFENG · 2010 to 2010
$151k
NIDDK NIH HHS R15 DK128757NIGMS NIH HHS P20 GM103429NIGMS NIH HHS R43 GM093621
6 · The paper itself

Abstract

Human erythropoietin (EPO) is a key cytokine in erythropoiesis by regulating differentiation of erythroid progenitor cells into red blood cells (RBCs). Plant cell cultures are considered as promising alternative bioproduction platforms for EPO. To overcome the bottlenecks of low protein productivity and secretion, EPO was expressed in tobacco BY-2 cells with a designer peptide tag, termed (SP)

Indexed as

ErythropoietinNicotianaCell DifferentiationErythroid Precursor CellsErythropoiesisHematopoietic Stem CellsHumansErythropoietinDifferentiationErythropoietinHematopoietic stem cellsPlant cell cultureRecombinant protein

Identifiers

PMID35777457
PMCPMC9492895
OpenAlexW4283688274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.