Evidence map›Paper›PMID 35777272›Full record

ArticlePlacenta2022

Placental pathology in spontaneous and iatrogenic preterm birth: Different entities with unique pathologic features.

Lucy T Brink, Drucilla J Roberts, Colleen A Wright, Daan G Nel, Pawel T Schubert, Theonia K Boyd, David R Hall, Hein Odendaal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Lucy T BrinkDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, Cape Town, South Africa.
Drucilla J RobertsMassachusetts General Hospital, Department of Pathology, 55 Fruit Street, Warren 219, Boston, MA, 02114, United States.
Colleen A WrightLancet Laboratories, Johannesburg, South Africa; Division of Anatomical Pathology, Tygerberg Hospital, National Health Laboratory Service, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, Cape Town, South Africa.
Daan G NelDepartment of Statistics and Actuarial Science, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa.
Pawel T SchubertDivision of Anatomical Pathology, Tygerberg Hospital, National Health Laboratory Service, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, Cape Town, South Africa.
Theonia K BoydDepartment of Pathology, Texas Children's Hospital, Houston, TX, United States.
David R HallDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, Cape Town, South Africa.
Hein OdendaalDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, Cape Town, South Africa. Electronic address: hjo@sun.ac.za.
Stellenbosch University · ZANational Health Laboratory Service · ZAMassachusetts General Hospital · USTexas Children's Hospital · US

Funding

Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD045935 · NICHD · UNIVERSITY OF SOUTH DAKOTA · PI ELLIOTT, AMY J · 2003 to 2015
$16.9M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01AA016501 · NIAAA · STELLENBOSCH UNIVERSITY · PI ODENDAAL, HENDRIK JOHANNES · 2006 to 2015
$10.0M
Safe PASSage Study Administrative Supplement - Effects of Overnight Maternal SleeU01HD055154 · NICHD · DM-STAT, INC. · PI DUKES, KIMBERLY A. · 2006 to 2017
$9.7M
Prenatal Alcohol Sudden Infant Death Syndrome/StillbirthU01HD045991 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI KINNEY, HANNAH CHASE · 2003 to 2015
$8.4M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD055155 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIFER, WILLIAM P., MYERS, MICHAEL MORGAN · 2006 to 2015
$7.1M
NIAAA NIH HHS U01 AA016501NICHD NIH HHS U01 HD045935NICHD NIH HHS U01 HD045991NICHD NIH HHS U01 HD055154NICHD NIH HHS U01 HD055155
6 · The paper itself

Abstract

introductionPlacental pathology is an important contributor to the understanding of preterm birth and reveals major differences between spontaneous preterm birth (SPTB) and iatrogenic preterm birth (IPTB). The aim of this study was to investigate these relationships.

methodsResearch midwives collected placentas from 1101 women with singleton pregnancies who were enrolled in the Safe Passage Study. Trained pathology technologists prepared and processed placenta specimens for macroscopic and microscopic examination by designated pathologists. Statistical analyses were done with STATISTICA version 13.

resultsIn SPTB we found more cases of accelerated villous maturation; however, the other features of maternal vascular malperfusion (MVM) were not present. The prevalence rate of funisitis was also increased. In IPTB, multiple features of MVM - accelerated villous maturation, distal villous hypoplasia, decidual arteriopathy, increased syncytial knots, increased perivillous fibrin, and prominent extravillous trophoblast were increased, as were features of fetal vascular malperfusion (FVM) - umbilical cord vessel thrombosis, avascular villi, and fetal vascular thrombosis. Increased syncytial knots were found in 26% of preterm stillbirths and in 29% of preterm infant demises as compared to 81% of IPTB infants alive at one year. DISCUSSION: SPTB and IPTB differ. The detected "abnormal" accelerated villous maturation pattern in SPTB and preterm demises, suggests an inability of the placenta to adapt and may be a trigger for SPTB. Funisitis was the only inflammatory response significant for SPTB. MVM and FVM are implicated in IPTB, but not an inflammatory process.

Indexed as

ChorioamnionitisPremature BirthFemaleHumansIatrogenic DiseaseInfant, NewbornInfant, PrematurePlacentaPregnancyIatrogenic preterm birthPlacental pathologySpontaneous preterm birth

Identifiers

PMID35777272
PMCPMC10555798
OpenAlexW4283070210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.