ArticleRedox biology2022
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.
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Article in Redox biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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19 citing papers in PubMed, 34 citations in OpenAlex.
- Bariatric surgery may alleviate MASLD by restoring mitochondria-lipid droplet structural and functional integrity through suppression of the Mitochondrial Fission Factor-Perilipin 5 axis.Molecular biomedicine · 2026Article
- Adipose Tissue Expandability as a Link Between Nutrition and Obesity-Related Metabolic Risk: Insights from Bariatric Surgery.Nutrients · 2026Review
- Oral Copaiba Oil-Resin Supplementation Reduces Plasma and Hepatic Oxidative Stress in Female and Male Hypothalamic-Obese Animals.Food science & nutrition · 2026Article
- Rapid and long-lasting remodelling of the blood transcriptome following bariatric surgery.International journal of obesity (2005) · 2026Article
- Visceral Obesity and Its Complications: The Role of Bioelectrical Impedance Analysis in Longevity Medicine.Metabolites · 2026Review
- Male obesity causes adipose mitochondrial dysfunction in FNature communications · 2026Article
- Liraglutide and renal mitochondrial homeostasis: targeting the "metabolism-inflammation-lithogenesis" axis in metabolic syndrome.Frontiers in pharmacology · 2026Review
- Adipose Tissue, at the Core of the Action of Incretin and Glucagon-Based Anti-Obesity Drugs.Current obesity reports · 2025Review
- Obesity promotes ARDS by modulating ceramide transfer protein-ceramide pathway and exacerbating oxidative stress/apoptosis in alveolar macrophages.Cellular and molecular life sciences : CMLS · 2025Article
- Association of Metabolic Score for Visceral Fat (METS-VF) with Gout Risk in Patients with Hypertension and Hyperuricemia: A Multicenter Study Based on the Chinese Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Interplay between the brain and adipose tissue: a metabolic conversation.EMBO reports · 2024Review
- Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.Nature communications · 2024Article
- ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.Cardiovascular diabetology · 2024Article
- White adipose tissue mitochondrial bioenergetics in metabolic diseases.Reviews in endocrine & metabolic disorders · 2023Review
- Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice.Cardiovascular diabetology · 2023Article
- Review
- Once a week consumption of Western diet over twelve weeks promotes sustained insulin resistance and non-alcoholic fat liver disease in C57BL/6 J mice.Scientific reports · 2023Article
- Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration.Frontiers in endocrinology · 2023Article
- Treatment with EV-miRNAs Alleviates Obesity-Associated Metabolic Dysfunction in Mice.International journal of molecular sciences · 2022Article
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Authors and funding
47 authors at 15 institutions in 6 countries.
Alba Gonzalez-FranquesaDepartment of Physiological Sciences, Universitat de Barcelona, 08907, Barcelona, Spain; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.
Pau Gama-PerezDepartment of Physiological Sciences, Universitat de Barcelona, 08907, Barcelona, Spain.
Marta KulisBiomedical Epigenomics Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.
Karolina SzczepanowskaCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, D-50931, Cologne, Germany.
Norma DahdahDepartment of Physiological Sciences, Universitat de Barcelona, 08907, Barcelona, Spain.
Sonia Moreno-GomezDepartment of Physiological Sciences, Universitat de Barcelona, 08907, Barcelona, Spain.
Ana Latorre-PellicerGrupo de Medicina Xenómica, CIBERER, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain; Unit of Clinical Genetics and Functional Genomics, Department of Pharmacology-Physiology, School of Medicine, University of Zaragoza, CIBERER-GCV02 and IIS-Aragon, 50009, Zaragoza, Spain.
Rebeca Fernández-RuizDepartment of Physiological Sciences, Universitat de Barcelona, 08907, Barcelona, Spain; Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Antoni Aguilar-MogasDepartment of Chemical Engineering, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Anne HoffmanHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Erika MonelliVascular Signalling Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08907, Barcelona, Spain.
Sara SaminoCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain; Department of Electronic Engineering, IISPV, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Joan Miró-BlanchCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain; Department of Electronic Engineering, IISPV, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Gregor OemerInstitute of Human Genetics, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Xavier DuranCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain; Institut d'Investigació Sanitària Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, 43007, Tarragona, Spain.
Estrella Sanchez-RebordeloDepartment of Physiology, CIMUS, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Marc SchneebergerDiabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, NY, 10065, New York, USA.
Merce ObachDiabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.
Joel MontaneDiabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; Blanquerna School of Health Science, Ramon Llull University, Barcelona, Spain.
Giancarlo CastellanoBiomedical Epigenomics Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.
Vicente ChapaprietaBiomedical Epigenomics Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.
Wenfei SunInstitute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
Lourdes NavarroDepartment of Physiological Sciences, Universitat de Barcelona, 08907, Barcelona, Spain.
Ignacio PrietoInstituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain.
Carlos CastañoDiabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Anna NovialsDiabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Ramon GomisDiabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Maria MonsalveInstituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain.
Marc ClaretCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.
Mariona GrauperaVascular Signalling Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08907, Barcelona, Spain.
Guadalupe SoriaExperimental 7T MRI Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Christian WolfrumInstitute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
Joan VendrellCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain; Institut d'Investigació Sanitària Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, 43007, Tarragona, Spain.
Sonia Fernández-VeledoCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain; Institut d'Investigació Sanitària Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, 43007, Tarragona, Spain.
Jose Antonio EnríquezCentro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain, CIBERFES, 28029, Madrid, Spain.
Angel CarracedoGrupo de Medicina Xenómica, CIBERER, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain; Fundación Pública Galega de Medicina Xenómica, SERGAS, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
José Carlos PeralesDepartment of Physiological Sciences, Universitat de Barcelona, 08907, Barcelona, Spain; Nutrition, Metabolism and Gene Therapy Group; Diabetes and Metabolism Program; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.
Rubén NogueirasDepartment of Physiology, CIMUS, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Laura HerreroCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain.
Aleksandra TrifunovicCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, D-50931, Cologne, Germany.
Markus A KellerInstitute of Human Genetics, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Oscar YanesCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029, Madrid, Spain; Department of Electronic Engineering, IISPV, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Marta Sales-PardoDepartment of Chemical Engineering, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Roger GuimeràDepartment of Chemical Engineering, Universitat Rovira i Virgili, 43007, Tarragona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain.
Matthias BlüherHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Germany Liebigstr. 20, 4103, Leipzig, Germany.
José Ignacio Martín-SuberoBiomedical Epigenomics Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain; Department of Basic Clinical Practice, Universitat de Barcelona, 08036, Barcelona, Spain.
Pablo M Garcia-RovesDepartment of Physiological Sciences, Universitat de Barcelona, 08907, Barcelona, Spain; Nutrition, Metabolism and Gene Therapy Group; Diabetes and Metabolism Program; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain. Electronic address: pgarciaroves@ub.edu.
Instituto de Salud Carlos III · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversidade de Santiago de Compostela · ESUniversitat de Barcelona · ESInstitut d'Investigació Biomédica de Bellvitge · ESETH Zurich · CHHelmholtz Zentrum München · DEHoward Hughes Medical Institute · USInnsbruck Medical University · ATInstitució Catalana de Recerca i Estudis Avançats · ESInstituto de Investigaciones Biomédicas Sols-Morreale · ESUniversity of Cologne · DECentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESNovo Nordisk Foundation · DKUniversitat Rovira i Virgili · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.
Indexed as
Insulin ResistanceAdipose TissueAnimalsHomeostasisIntra-Abdominal FatMiceObesityProteomicsCaloric restrictionExerciseHuman obesityMetabolic fingerprintMetabolic plasticityMitochondrial dysfunctionMulti-organ approachObesityTwo-steps bariatric surgeryVisceral adipose tissue
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