Evidence map›Paper›PMID 35776964›Full record

ArticleSleep2022

The natural history of insomnia: high sleep reactivity interacts with greater life stress to predict the onset of acute insomnia.

Jamie L Walker, Ivan Vargas, Christopher L Drake, Jason G Ellis, Alexandria Muench, Michael L Perlis

Open access · bronzeAbstract read
In one paragraph

Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Effects of motivational music on sleep quality for caregivers of patients with advanced cancer: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Jamie L WalkerDepartment of Psychological Science, University of Arkansas, Fayetteville, AR, USA.ORCID 0000-0003-2256-3931
Ivan VargasDepartment of Psychological Science, University of Arkansas, Fayetteville, AR, USA.ORCID 0000-0002-0787-5630
Christopher L DrakeDepartment of Medicine, Division of Sleep Medicine, Sleep Disorders and Research Center, Henry Ford Hospital, Novi, MI, USA.ORCID 0000-0002-5486-3587
Jason G EllisDepartment of Psychology, Northumbria Center for Sleep Research, Northumbria University, Newcastle, UK.ORCID 0000-0002-8496-520X
Alexandria MuenchDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Michael L PerlisDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
University of Arkansas at Fayetteville · USUniversity of Pennsylvania · USHenry Ford Hospital · USNorthumbria University · GB

Funding

Prospective Assessment of The Etiology of Insomnia in Middle Aged & Elder AdultsR01AG041783 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PERLIS, MICHAEL LLOYD · 2013 to 2016
$2.4M
Behavioral Sleep Medicine: Training in Sleep and AgingK24AG055602 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Michael Lloyd Perlis · 2017 to 2026
$1.6M
Circadian and Ultradian Cortisol Rhythms in Chronic Sleep Continuity DisturbanceK23HL141581 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VARGAS, IVAN · 2019 to 2023
$677k
NHLBI NIH HHS K23 HL141581NIA NIH HHS K24 AG055602NIA NIH HHS L30 AG060532NIA NIH HHS R01 AG041783NIH HHS R01AG041783
6 · The paper itself

Abstract

STUDY

objectivesPrior research suggests that some individuals have a predisposition to experience insomnia following acute stressors (i.e. sleep reactivity). The present study was a proof of concept and specifically aimed to provide additional empirical evidence that the link between stressful life events and the onset of acute insomnia is moderated by sleep reactivity.

methodsAbout 1,225 adults with a history of good sleep (Mage = 53.2 years, 68% female, 83% white) were recruited nationwide for an online study on sleep health. Participants completed surveys to assess sleep reactivity (baseline), sleep patterns (daily sleep diary), and stressful life events (weekly survey). All daily and weekly measures were completed for a one-year period. Sleep diary data were used to identify sleep initiation/maintenance difficulties, including whether they met criteria for acute insomnia at any point during the one-year interval.

resultsParticipants with high sleep reactivity compared to low sleep reactivity were at 76% increased odds of developing acute insomnia during the one-year interval. In general, greater weekly stressful life events were associated with greater insomnia during the subsequent week. Those participants with high sleep reactivity demonstrated a stronger relationship between weekly stressful life events and insomnia, such that they reported the greatest levels of insomnia following weeks where they experienced a greater number of stressful life events.

conclusionsThese results further support the sleep reactivity model of insomnia, and specifically, provide evidence that sleep reactivity predicts the incidence of acute insomnia in a sample of participants with no history of insomnia.

Indexed as

Sleep Initiation and Maintenance DisordersAdultFemaleHumansIncidenceMaleSleepStress, PsychologicalSurveys and Questionnairesacute insomniasleep reactivitystress

Identifiers

PMID35776964
PMCPMC9453617
OpenAlexW4283775599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.