Evidence map›Paper›PMID 35776651›Full record

ArticleSTAR protocols2022

Simultaneous recording of neuronal and vascular activity in the rodent brain using fiber-photometry.

Wei-Ting Zhang, Tzu-Hao Harry Chao, Guohong Cui, Yen-Yu Ian Shih

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Space wandering in the rodent default mode network.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wei-Ting ZhangCenter for Animal MRI, Biomedical Research Imaging Center, Department of Neurology, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7025, USA. Electronic address: wtzhang@email.unc.edu.
Tzu-Hao Harry ChaoCenter for Animal MRI, Biomedical Research Imaging Center, Department of Neurology, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7025, USA. Electronic address: tzuhao@email.unc.edu.
Guohong CuiIn vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA.
Yen-Yu Ian ShihCenter for Animal MRI, Biomedical Research Imaging Center, Department of Neurology, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7025, USA.
University of North Carolina at Chapel Hill · USNational Institutes of Health · US

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A Herman · 2003 to 2026
$46.3M
Basal Ganglia in Health and DiseaseZIAES103310 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUI, GUOHONG · 2016 to 2025
$23.6M
UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
UNC-CH NADIA Underage Drinking and Adult Brain Morphology in RatsU01AA020023 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CREWS, FULTON T · 2010 to 2024
$7.5M
Circuit Mechanisms Governing the Default Mode NetworkR01MH126518 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Vinod Menon, Yen-Yu Ian Shih · 2021 to 2026
$4.3M
Mechanisms underlying positive and negative BOLD in the striatumRF1MH117053 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2018 to 2019
$4.0M
Chemogenetic Dissection of Neuronal and Astrocytic Compartment of the BOLD SignalR01MH111429 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2016 to 2020
$2.7M
Functional dissection of therapeutic deep brain stimulation circuitryR01NS091236 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2015 to 2019
$2.0M
Computational modeling of dynamic causal brain circuits underlying cognitive dysfunction in Alzheimer's diseaseRF1NS086085 · NINDS · STANFORD UNIVERSITY · PI MENON, VINOD · 2021 to 2021
$2.0M
9.4T Small Animal MRI scanner at UNCS10OD026796 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$2.0M
AVANCE NEO upgrade for the BioSpec 9.4T/30cm MRI system at UNCS10MH124745 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$600k
Intramural NIH HHS ZIA ES103310NIAAA NIH HHS P60 AA011605NIAAA NIH HHS U01 AA020023NICHD NIH HHS P50 HD103573NIH HHS S10 OD026796NIMH NIH HHS R01 MH111429NIMH NIH HHS R01 MH126518NIMH NIH HHS RF1 MH117053NIMH NIH HHS S10 MH124745NINDS NIH HHS P30 NS045892NINDS NIH HHS R01 NS091236NINDS NIH HHS RF1 NS086085
6 · The paper itself

Abstract

Coupling of hemodynamic responses to neuronal activity is the foundation of several functional neuroimaging techniques. Here, we provide three fiber-photometry approaches to simultaneously measure neuronal and vascular signals in the rodent brain using a spectrometer-based system. Two out of these three approaches allow the removal of hemoglobin (Hb)-absorption artifacts and restore the underlying neuronal activity. This technique is applicable to different fluorescent sensors and provides a more accurate measurement of hemodynamic response function in any location of the rodent brain. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2022).

Indexed as

BrainRodentiaAnimalsHemoglobinsNeuronsPhotometryHemoglobinsBioinformaticsModel OrganismsMolecular/Chemical ProbesNeuroscience

Identifiers

PMID35776651
PMCPMC9243291
OpenAlexW4283311695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.