ArticleAging2022
Epigenetic clocks and their association with trajectories in perceived discrimination and depressive symptoms among US middle-aged and older adults.
Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 27 citations in OpenAlex.
- Capturing wear in wear and tear: The negative-affect reactivity linked to discrimination is associated with biological age across two national samples of adults in the United States.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Epigenetic aging markers in the association between frailty and mortality among U.S. adults.BMC medicine · 2026Article
- Mental health across the lifecourse as predictors of epigenetic aging from a longitudinal birth cohort in the United States.Journal of affective disorders · 2026Article
- Article
- Epigenetic clocks moderate the impact of marital status transitions on health in older adults.PloS one · 2026Article
- Social relationships and epigenetic markers of aging in middle-aged and older adults: cross-sectional and prospective analyses.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Psychological distress in older adults: associations with epigenetic markers of ageing, inflammation, and depression, and joint effects on mortality.Brain, behavior, & immunity - health · 2025Article
- Telomere Length, Epigenetic Age Acceleration, and Mortality Risk in US Adult Populations: An Additive Bayesian Network Analysis.Aging cell · 2025Article
- Cumulative neighborhood disadvantage and racial and geographic disparities in epigenetic aging.SSM - population health · 2025Article
- Examining the Health Risk Pathways Between Discrimination and Accelerated Biological Aging Among a Population-Based Sample of Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Discrimination, Coping, and DNAm Accelerated Aging Among African American Mothers of the InterGEN Study.Epigenomes · 2025Article
- Depressive symptoms partially mediate the relationship between psychosocial factors and epigenetic age acceleration in a multi-racial/ethnic sample of older adults.Brain, behavior, & immunity - health · 2025Article
- Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025Review
- Major experiences of perceived discrimination across life and biological aging.Psychoneuroendocrinology · 2025Article
- Gerotherapeutics: aging mechanism-based pharmaceutical and behavioral interventions to reduce cancer racial and ethnic disparities.Journal of the National Cancer Institute · 2025Review
- Depression, Subjective Health, Obesity, and Multimorbidity are Associated with Epigenetic Age Acceleration.Journal of biomedical and life sciences · 2025Article
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Article
- Are depressive symptoms associated with biological aging in a cross-sectional analysis of adults over age 50 in the United States.Psychology and aging · 2024Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPerceived discrimination may be associated with accelerated aging later in life, with depressive symptoms acting as potential mediator.
methodsA nationally representative sample of older adults was used [Health and Retirement Study 2010-2016, Age: 50-100 y in 2016,
resultsOverall, and mostly among female and NHW participants, greater RPD in 2010-2012 had a significant adverse total effect on epigenetic aging [2016: DNAm GrimAge, DunedinPoAm38 (MPOA), Levine (PhenoAge) and Horvath 2], with 20-50% of this effect being explained by a pure indirect effect through DEP in 2014-2016. Among females, sustained elevated DEP (2010-2016) was associated with greater LIN DNAm age (β ± SE: +1.506 ± 0.559,
conclusionsSustained elevations in DEP and RPD were associated with select biological aging measures, consistently among women and White adults, with DEP acting as mediator in several RPD-EPICLOCK associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.