Evidence map›Paper›PMID 35776523›Full record

ArticleAmerican journal of respiratory cell and molecular biology2022

Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization.

Jose F Perez-Zoghbi, Dannah Rae Sajorda, Daniel A Webb, Leggy A Arnold, Charles W Emala, Gene T Yocum

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Anxiolytics for Bronchodilation: Refinements to GABAAmerican journal of respiratory cell and molecular biology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jose F Perez-ZoghbiDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; and.
Dannah Rae SajordaDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; and.
Daniel A WebbDepartment of Chemistry and Biochemistry and.
Leggy A ArnoldDepartment of Chemistry and Biochemistry and.
Charles W EmalaDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; and.
Gene T YocumDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; and.
Columbia University · USUniversity of Wisconsin–Milwaukee · US

Funding

Neuromuscular blocker-induced asthma during anesthesiaR01GM065281 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2003 to 2018
$5.4M
Anesthetics' Effects on Physiological Responses Modulated by Peripheral GABAA ReceptorsR35GM140880 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2021 to 2025
$2.0M
Targeting airway smooth muscle chloride fluxes for bronchorelaxationR01HL122340 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2015 to 2018
$1.6M
GABAA Receptor-Mediated Modulation of Lung InflammationK08HL140102 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YOCUM, GENE THOMAS · 2018 to 2022
$831k
THERAPEUTIC TARGETING OF THE GABAA CHANNEL ON AIRWAY SMOOTH MUSCLEK08GM093137 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GALLOS, GEORGE · 2010 to 2014
$628k
Development of microencapsulated PI301 targeting lung GABAergic signalingR43HL162474 · NHLBI · PANTHERICS INCORPORATED · PI STAFFORD, DOUGLAS C. · 2022 to 2022
$256k
A novel asthma drug candidate targeting the GABAergic system in lung inflammationR41HL147658 · NHLBI · PANTHERICS INCORPORATED · PI ARNOLD, ALEXANDER · 2019 to 2019
$225k
NHLBI NIH HHS HL122340NHLBI NIH HHS K08 HL140102NHLBI NIH HHS R01 HL122340NHLBI NIH HHS R41 HL147658NHLBI NIH HHS R43 HL162474NIGMS NIH HHS GM065281NIGMS NIH HHS K08 GM093137NIGMS NIH HHS R01 GM065281NIGMS NIH HHS R35 GM140880NIH HHS GM140880NIH HHS HL140102NIH HHS HL147658
6 · The paper itself

Abstract

Asthma is a common respiratory disease characterized, in part, by excessive airway smooth muscle (ASM) contraction (airway hyperresponsiveness). Various GABA

Indexed as

AsthmaCalciumAnimalsCalcium SignalingFlumazenilgamma-Aminobutyric AcidInositolLigandsLungMethacholine ChlorideMiceMuscle ContractionMuscle, SmoothPicrotoxinCalciumFlumazenilgamma-Aminobutyric AcidInositolLigandsMethacholine ChloridePicrotoxinasthmabenzodiazepineGABAA receptorIP3 receptorprecision-cut lung slice

Identifiers

PMID35776523
PMCPMC9564932
OpenAlexW4283740269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.