ArticleInfection2023
Differentiation of hepatic alveolar echinococcosis with a hemangioma-like pattern compared to typical liver hemangioma using contrast-enhanced ultrasound: a pilot study.
Article in Infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 13 citations in OpenAlex.
- Screening for alveolar echinococcosis in household members of affected patients: A cross-sectional study with a pooled comparison to endemic population screenings.One health (Amsterdam, Netherlands) · 2026Article
- Quantitative Contrast-Enhanced Ultrasound Characterization of Perilesional Perfusion and Its Association with CD34-Positive Cell Density in a Rat Model of Hepatic Alveolar Echinococcosis.Pathogens (Basel, Switzerland) · 2026Article
- Diagnosis of hepatic alveolar echinococcosis:18F-FDG-PET activity compared to the Echinococcus multilocularis Ulm Ultrasound Classification.Nuklearmedizin. Nuclear medicine · 2026Article
- Diagnostic performance comparison of two ultrasound classification systems for hepatic alveolar echinococcosis: a single-center retrospective study.Infectious diseases of poverty · 2026Article
- Sonographic double patterns in hepatic alveolar echinococcosis according to the echinococcosis multilocularis ultrasound classification.Parasitology research · 2025Article
- Enhanced diagnostic accuracy of contrast-enhanced ultrasound in liver space-occupying lesions: superior sensitivity and specificity over conventional ultrasound.American journal of cancer research · 2025Article
- Pictorial review of hepatic echinococcosis: Ultrasound imaging and differential diagnosis.World journal of gastroenterology · 2024Review
- Computed tomography angiography of liver alveococcosis: a case report.Journal of medical case reports · 2024Article
- Can contrast-enhanced ultrasound differentiate the type of hepatic echinococcosis: cystic echinococcosis or alveolar echinococcosis?Parasites & vectors · 2023Article
- [Diagnostic delaying factors in hepatic alveolar echinococcosis].Deutsche medizinische Wochenschrift (1946) · 2023Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeEchinococcus multilocularis infects humans as a false intermediate host, primarily with intrahepatic manifestation. Incorrect diagnostic interpretation of these liver tumors, especially the hemangioma-like pattern, can lead to progressive disease. The aim of the study was to investigate the differentiation of typical hemangioma and a hemangioma-like pattern of E. multilocularis using contrast-enhanced ultrasound (CEUS).
methodsThis prospective clinical pilot study comprised patients with hemangioma (n = 14) and patients with alveolar echinococcosis (AE) and hemangioma-like pattern (n = 7). Inclusion criteria were the detection of a liver lesion according to a hemangioma-like pattern on E. multilocularis Ulm classification-ultrasound (EMUC-US) and "confirmed" or "probable" AE according to WHO case definition. The comparison group had hepatic hemangioma with typical B-scan sonographic morphology. All participants underwent conventional and contrast-enhanced ultrasonography.
resultsThe patient group comprised five men (71.4%) and two women (28.6%) with a mean average age of 64.1 ± 11.2 years. The patient group with hemangioma comprised nine female subjects (64.3%) and five male subjects (35.7%) with a mean average age of 56.1 ± 12.0 years. Early arterial bulbous ring enhancement (p < 0.0001) and iris diaphragm phenomenon could only be visualized in the patients with hemangioma (p < 0.0001). Furthermore, the patients with hemangioma exhibited hyperenhancement in the late phase (p = 0.0003). In contrast, the patients exhibited typical early arterial rim enhancement (p < 0.0001) and, in the portal venous and late phase, complete or incomplete non-enhancement (black hole sign; p = 0.0004). CONSLUSION: The behavior of hemangioma-like AE lesions and typical liver hemangiomas is significantly different on CEUS. AE should be considered as a possible differential diagnosis, especially in high-endemic areas.
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