Evidence map›Paper›PMID 35775996›Full record

ArticleBiometrics2023

Multiwave validation sampling for error-prone electronic health records.

Bryan E Shepherd, Kyunghee Han, Tong Chen, Aihua Bian, Shannon Pugh, Stephany N Duda, Thomas Lumley, William J Heerman, Pamela A Shaw

Open access · greenAbstract read
In one paragraph

Article in Biometrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 16 citations in OpenAlex.

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  14. Optimal multiwave validation of secondary use data with outcome and exposure misclassification.The Canadian journal of statistics = Revue canadienne de statistique · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Bryan E ShepherdDepartment of Biostatistics, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0002-3758-5992
Kyunghee HanDepartment of Mathematics, Statistics, and Computer Science, University of Illinois at Chicago, Chicago.ORCID 0000-0002-8703-9973
Tong ChenDepartment of Statistics, University of Auckland, Auckland, New Zealand.
Aihua BianDepartment of Biostatistics, Vanderbilt University, Nashville, Tennessee.
Shannon PughDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Stephany N DudaDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.
Thomas LumleyDepartment of Statistics, University of Auckland, Auckland, New Zealand.ORCID 0000-0003-4255-5437
William J HeermanDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-9706-6860
Pamela A ShawBiostatistics Unit, Kaiser Permanente Washington Health Research Institute, Seattle, Washington.ORCID 0000-0003-1883-8410
Vanderbilt University Medical Center · USUniversity of Auckland · NZVanderbilt University · USKaiser Permanente Washington Health Research Institute · USUniversity of Illinois Chicago · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Statistical methods and designs for correlated outcome and covariate errors in studies of HIV/AIDSR37AI131771 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pamela A Shaw, Bryan Earl Shepherd · 2023 to 2026
$3.4M
Statistical methods for correlated outcome and covariate errors in studies of HIV/AIDSR01AI131771 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHAW, PAMELA A, SHEPHERD, BRYAN EARL · 2018 to 2022
$3.0M
NCATS NIH HHS UL1 TR002243NIAID NIH HHS R01 AI131771NIAID NIH HHS R37 AI131771
6 · The paper itself

Abstract

Electronic health record (EHR) data are increasingly used for biomedical research, but these data have recognized data quality challenges. Data validation is necessary to use EHR data with confidence, but limited resources typically make complete data validation impossible. Using EHR data, we illustrate prospective, multiwave, two-phase validation sampling to estimate the association between maternal weight gain during pregnancy and the risks of her child developing obesity or asthma. The optimal validation sampling design depends on the unknown efficient influence functions of regression coefficients of interest. In the first wave of our multiwave validation design, we estimate the influence function using the unvalidated (phase 1) data to determine our validation sample; then in subsequent waves, we re-estimate the influence function using validated (phase 2) data and update our sampling. For efficiency, estimation combines obesity and asthma sampling frames while calibrating sampling weights using generalized raking. We validated 996 of 10,335 mother-child EHR dyads in six sampling waves. Estimated associations between childhood obesity/asthma and maternal weight gain, as well as other covariates, are compared to naïve estimates that only use unvalidated data. In some cases, estimates markedly differ, underscoring the importance of efficient validation sampling to obtain accurate estimates incorporating validated data.

Indexed as

AsthmaGestational Weight GainPediatric ObesityChildElectronic Health RecordsFemaleHumansPregnancyProspective Studiesgeneralized rakingmeasurement errorobesitytwo-phase samplingweight gain

Identifiers

PMID35775996
PMCPMC10525037
OpenAlexW4283751764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.