Evidence map›Paper›PMID 35775390›Full record

Trial reportEuropean journal of heart failure2022

A pilot clinical trial of cell therapy in heart failure with preserved ejection fraction.

Bojan Vrtovec, Sabina Frljak, Gregor Poglajen, Gregor Zemljic, Andraz Cerar, Matjaz Sever, Francois Haddad, Joseph C Wu

Registry-linked trialOpen access · hybridAbstract readClinical Trial
In one paragraph

Trial report in European journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02923609 (A PILOT TRIAL OF CELL THERAPY IN HEART FAILURE WITH PRESERVED EJECTION FRACTION), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02923609 phase2completednot on this map

A pilot trial of cell therapy in heart failure with preserved ejection fraction

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2016 to 2022Enrolled30ConditionsHeart Failure With Normal Ejection FractionArmsCell Therapy
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. TransEndocardial Injection of Autologous Expanded CD34Stem cell reviews and reports · 2026
    Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Bojan VrtovecAdvanced Heart Failure and Transplantation Center, Department of Cardiology, UMC Ljubljana, Ljubljana, Slovenia.
Sabina FrljakAdvanced Heart Failure and Transplantation Center, Department of Cardiology, UMC Ljubljana, Ljubljana, Slovenia.
Gregor PoglajenAdvanced Heart Failure and Transplantation Center, Department of Cardiology, UMC Ljubljana, Ljubljana, Slovenia.
Gregor ZemljicAdvanced Heart Failure and Transplantation Center, Department of Cardiology, UMC Ljubljana, Ljubljana, Slovenia.
Andraz CerarAdvanced Heart Failure and Transplantation Center, Department of Cardiology, UMC Ljubljana, Ljubljana, Slovenia.
Matjaz SeverDepartment of Hematology, UMC Ljubljana, Ljubljana, Slovenia.
Francois HaddadStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Joseph C WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Ljubljana University Medical Centre · SICardiovascular Institute of the South · USStanford University · USUniversity of Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe investigated the effects of CD34 METHODS AND

resultsIn a prospective pilot study, we enrolled 30 patients with HFpEF. In Phase 1, patients were treated with medical therapy for 6 months. Thereafter, all patients underwent CD34

conclusionsIn this non-randomized trial, transendocardial CD34 CLINICAL

trial registrationClinicalTrials.gov NCT02923609.

Indexed as

Heart FailureCell- and Tissue-Based TherapyHumansNatriuretic Peptide, BrainPeptide FragmentsPilot ProjectsProspective StudiesStroke VolumeNatriuretic Peptide, BrainPeptide FragmentsCell therapyDiastolic functionHeart failureHeart failure with preserved ejection fraction

Identifiers

PMID35775390
PMCPMC9540623
OpenAlexW4283745005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.