Evidence map›Paper›PMID 35775377›Full record

ArticleInternational journal of oncology2022

CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas.

Andrzej T Slominski, Anna A Brożyna, Tae-Kang Kim, Mahmoud M Elsayed, Zorica Janjetovic, Shariq Qayyum, Radomir M Slominski, Allen S W Oak, Changzhao Li, Ewa Podgorska and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in International journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. The vitamin DAmerican journal of physiology. Cell physiology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Recent Advances in Vitamin D Biology: Something New under the Sun.The Journal of investigative dermatology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Andrzej T Slominski *Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Anna A Brożyna *Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Tae-Kang KimDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Mahmoud M ElsayedDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Zorica JanjetovicDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Shariq QayyumDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Radomir M SlominskiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Allen S W OakDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Changzhao LiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Ewa PodgorskaDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Wei LiDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Anton M JettenCell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Robert C TuckeySchool of Molecular Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Edith K Y TangSchool of Molecular Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Craig ElmetsDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
Mohammad AtharDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35292, USA.
University of Alabama at Birmingham · USUniversity of Western Australia · AUNational Institutes of Health · USUniversity of Tennessee Health Science Center · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Nuclear receptors: action, functions, and roles in diseaseZIAES101586 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JETTEN, ANTON M · 2009 to 2025
$13.5M
NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0M
RXR Rexinoids for Cancer ChemopreventionP01CA210946 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ATHAR, MOHAMMAD · 2017 to 2021
$7.3M
Mechanism of action and function of novel secosteroid 20(OH)D3 in the skinR01AR073004 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANDRZEJ T SLOMINSKI · 2018 to 2026
$2.9M
Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancerR01CA240447 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LI, WEI, ZHOU, MUXIANG · 2020 to 2024
$2.7M
Selective Targeting Survivin for Cancer TherapyR01CA193609 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LI, WEI · 2016 to 2020
$1.9M
Topical Chemoprevention of Skin Cancer BiomarkersR01CA193885 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELMETS, CRAIG A · 2016 to 2022
$1.7M
Significance of metabolic activation of lumisterol in the skinR01AR071189 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SLOMINSKI, ANDRZEJ T · 2017 to 2021
$1.6M
Canonical and non-canonical vitamin D activation pathways in systemic lupusR21AI149267 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RAMAN, CHANDER, SLOMINSKI, ANDRZEJ T · 2020 to 2021
$408k
UV Photodamage to the Skin: Prevention by Mutant p53 ImmunizationR21ES034595 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELMETS, CRAIG A · 2022 to 2023
$408k
BLRD VA I01 BX004293NCATS NIH HHS TL1 TR001880NCI NIH HHS P01 CA210946NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA193609NCI NIH HHS R01 CA193885NCI NIH HHS R01 CA240447NIAID NIH HHS R21 AI149267NIAMS NIH HHS R01 AR071189NIAMS NIH HHS R01 AR073004NIEHS NIH HHS R21 ES034595
6 · The paper itself

Abstract

Hydroxyderivatives of vitamin D3, including classical 1,25(OH)

Indexed as

Basal Cell CarcinomaCarcinoma, Squamous CellCholesterol Side-Chain Cleavage EnzymeVitamin DAnimalsbeta CateninCholecalciferolHumansLow Density Lipoprotein Receptor-Related Protein-2MiceReceptors, CalcitriolSkin NeoplasmsZinc Finger Protein GLI1beta CateninCholecalciferolCholesterol Side-Chain Cleavage EnzymeLow Density Lipoprotein Receptor-Related Protein-2Receptors, CalcitriolVitamin DZinc Finger Protein GLI1basal cell carcinomakeratinocytesretinoid‑­related orphan receptor αretinoid‑related orphan receptor γsquamous cell carcinomavitamin Dvitamin D receptor

Identifiers

PMID35775377
PMCPMC9262157
OpenAlexW4283759293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.