Evidence map›Paper›PMID 35775109›Full record

ArticleESC heart failure2022

Modified reverse shock index predicts early outcomes of heart failure with reduced ejection fraction.

Gyu Chul Oh, Seokyung An, Hae-Young Lee, Hyun-Jai Cho, Eun-Seok Jeon, Sang Eun Lee, Jae-Joong Kim, Seok-Min Kang, Kyung-Kuk Hwang, Myeong-Chan Cho and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Utility of shock index to predict mortality risk in decompensated heart failure.Journal of the colleges of medicine of South Africa · 2025
    Article
  2. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 3 countries.

Gyu Chul OhDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID 0000-0003-3056-8791
Seokyung AnDepartment of Biomedical Science, Seoul National University Graduate School, Seoul, South Korea.
Hae-Young LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Hyun-Jai ChoDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Eun-Seok JeonDepartment of Internal Medicine, Sungkyunkwan University College of Medicine, Seoul, South Korea.
Sang Eun LeeDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jae-Joong KimDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Seok-Min KangDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Kyung-Kuk HwangDepartment of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, South Korea.
Myeong-Chan ChoDepartment of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, South Korea.
Shung Chull ChaeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Dong-Ju ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Byung-Su YooDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Kye Hun KimDepartment of Internal Medicine, Heart Research Center of Chonnam National University, Gwangju, South Korea.
Sue K ParkCancer Research Institute, Seoul National University, Seoul, South Korea.
Sang Hong BaekDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Catholic University of Korea · KRChungbuk National University · KRSeoul National University Hospital · KRUlsan College · KRYonsei University · KRChonnam National University · KRKyungpook National University · KRSeoul National University · KRSeoul National University Bundang Hospital · KRSeoul National University of Science and Technology · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsIncreased blood pressure (BP) and decreased heart rate (HR) are signs of stabilization in patients admitted for acute HF. Changes in BP and HR during admission and their correlation with outcomes were assessed in hospitalized patients with heart failure (HF) with reduced ejection fraction (HFrEF).

methodsA novel modified reverse shock index (mRSI), defined as the ratio between changes in systolic BP and HR during admission, was devised, and its prognostic value in the early outcomes of acute HF was assessed using the Korean Acute HF registry.

resultsAmong 2697 patients with HFrEF (mean age 65.8 ± 14.9 years, 60.6% males), patients with mRSI ≥1.25 at discharge were significantly younger and were more likely to have de novo HF. An mRSI ≥1.25 was associated with a significantly lower incidence of 60-day and 180-day all-cause mortality [hazard ratio (HR) 0.49, 95% confidence interval (CI) 0.31-0.77; HR 0.62, 95% CI 0.45-0.85, respectively], compared with 1 ≤ mRSI < 1.25 (all P < 0.001). Conversely, an mRSI <0.75 was associated with a significantly higher incidence of 60-day and 180-day all-cause mortality (adjusted HR 2.08, 95% CI 1.19-3.62; HR 2.24, 95% CI 1.53-3.27; all P < 0.001). The benefit associated with mRSI ≥1.25 was consistent in sub-group analyses. The correlation of mRSI and outcomes were also consistent regardless of admission SBP, presence of atrial fibrillation, or use of beta blockers at discharge.

conclusionsIn patients hospitalized for HFrEF, the mRSI was a significant predictor of early outcomes. The mRSI could be used as a tool to assess patient status and guide physicians in treating patients with HFrEF.

Indexed as

Heart FailureVentricular Dysfunction, LeftAdrenergic beta-AntagonistsAgedAged, 80 and overFemaleHospitalizationHumansMaleMiddle AgedStroke VolumeAdrenergic beta-AntagonistsBlood pressureHeart failureHeart rateMortality

Identifiers

PMID35775109
PMCPMC9715832
OpenAlexW4283743918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.