Evidence map›Paper›PMID 35775049›Full record

ArticleFrontiers in neurology2022

Analysis of Side Effects Following Vaccination Against COVID-19 Among Individuals With Multiple Sclerosis Treated With DMTs in Poland.

Agata Czarnowska, Joanna Tarasiuk, Olga Zajkowska, Marcin Wnuk, Monika Marona, Klaudia Nowak, Agnieszka Słowik, Anna Jamroz-Wiśniewska, Konrad Rejdak, Beata Lech and 42 more

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Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors at 15 institutions in 1 country.

Agata CzarnowskaDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Joanna TarasiukDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Olga ZajkowskaFaculty of Economic Sciences, University of Warsaw, Warsaw, Poland.
Marcin WnukDepartment of Neurology, Jagiellonian University Medical College, Krakow, Poland.
Monika MaronaDepartment of Neurology, Jagiellonian University Medical College, Krakow, Poland.
Klaudia NowakDepartment of Neurology, Jagiellonian University Medical College, Krakow, Poland.
Agnieszka SłowikDepartment of Neurology, Jagiellonian University Medical College, Krakow, Poland.
Anna Jamroz-WiśniewskaDepartment of Neurology, Medical University of Lublin, Lublin, Poland.
Konrad RejdakDepartment of Neurology, Medical University of Lublin, Lublin, Poland.
Beata LechNeurology Clinic With Brain Stroke Sub-Unit, Clinical Hospital No. 2 in Rzeszow, Lwowska, Poland.
Małgorzata PopielNeurology Clinic With Brain Stroke Sub-Unit, Clinical Hospital No. 2 in Rzeszow, Lwowska, Poland.
Iwona Rościszewska-ŻukowskaDepartment of Neurology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland.
Adam PerencNeurology Clinic With Brain Stroke Sub-Unit, Clinical Hospital No. 2 in Rzeszow, Lwowska, Poland.
Halina Bartosik-PsujekDepartment of Neurology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland.
Mariola Świderek-MatysiakDepartment of Neurology, Medical University of Lodz, Łódz, Poland.
Małgorzata SigerDepartment of Neurology, Medical University of Lodz, Łódz, Poland.
Agnieszka CiachDepartment of Neurology, Medical University of Lodz, Łódz, Poland.
Agata WalczakDepartment of Neurology, Medical University of Lodz, Łódz, Poland.
Anna JurewiczDepartment of Neurology, Medical University of Lodz, Łódz, Poland.
Mariusz StasiołekDepartment of Neurology, Medical University of Lodz, Łódz, Poland.
Karolina KaniaDepartment of Neurology, Poznan University of Medical Sciences, Poznań, Poland.
Klara DyczkowskaDepartment of Neurology, Poznan University of Medical Sciences, Poznań, Poland.
Alicja Kalinowska-ŁyszczarzDivision of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Poznań, Poland.
Weronika GalusDepartment of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Anna Walawska-HrycekDepartment of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Ewa KrzystanekDepartment of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Justyna Chojdak-ŁukasiewiczDepartment of Neurology, Wroclaw Medical University, Wroclaw, Poland.
Jakub UbyszDepartment of Neurology, Wroclaw Medical University, Wroclaw, Poland.
Anna Pokryszko-DraganDepartment of Neurology, Wroclaw Medical University, Wroclaw, Poland.
Katarzyna Kapica-TopczewskaDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Monika ChorążyDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Marcin BazylewiczDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Anna MirończukDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Joanna KulikowskaDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Jan KochanowiczDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Marta BiałekDepartment of Neurology, Regional Specialised Hospital No. 4 in Bytom, Bytom, Poland.
Małgorzata StolarzDepartment of Neurology, Regional Specialised Hospital No. 4 in Bytom, Bytom, Poland.
Katarzyna Kubicka-BączykDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Natalia NiedzielaDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Paweł WarmusDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Monika Adamczyk-SowaDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Aleksandra Podlecka-PiçtowskaDepartment of Neurology, Medical University of Warsaw, Warsaw, Poland.
Monika NojszewskaDepartment of Neurology, Medical University of Warsaw, Warsaw, Poland.
Beata Zakrzewska-PniewskaDepartment of Neurology, Medical University of Warsaw, Warsaw, Poland.
Elżbieta JasińskaJan Kochanowski University, Collegium Medicum, Kielce, Poland.
Jacek ZaborskiDepartment of Neurology and Neurorehabilitation, Miedzyleski Szpital Specjalistyczny, Warsaw, Poland.
Marta Milewska-JȩdrzejczakDepartment of Neurology and Ischemic Strokes, Medical University of Lodz, Lodz, Poland.
Jacek ZwiernikNeurology Ward, Provincial Specialist Hospital, Olsztyn, Poland.
Beata ZwiernikDepartment of Neurology, University of Warmia and Mazury, Olsztyn, Poland.
Andrzej PotemkowskiDepartment of Clinical Psychology and Psychoprophylaxis, University of Szczecin, Szczecin, Poland.
Waldemar BrolaDepartment of Neurology, Specialist Hospital in Końskie, Collegium Medicum, Jan Kochanowski University in Kielce, Kielce, Poland.
Alina KułakowskaDepartment of Neurology, Medical University of Białystok, Białystok, Poland.
Medical University of Białystok · PLMedical University of Lodz · PLMedical University of Silesia · PLJagiellonian University · PLMedical University of Warsaw · PLPoznan University of Medical Sciences · PLWroclaw Medical University · PLJan Kochanowski University · PLMedical University of Lublin · PLRzeszów University · PLUniversity of Warmia and Mazury in Olsztyn · PLWojewódzki Szpital Specjalistyczny nr 4 w Bytomiu · PLMiędzyleski Szpital Specjalistyczny w Warszawie · PLUniversity of Szczecin · PLUniversity of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Since vaccination against COVID-19 is available for over a year and the population of immunized individuals with autoimmune disorders is higher than several months before, an evaluation of safety and registered adverse events can be made. We conducted a large study of side effects following the COVID-19 vaccine among patients with multiple (MS) sclerosis treated with disease-modifying therapies (DMTs) and analyzed factors predisposing for particular adverse events. Methods: We gathered data of individuals with MS treated with DMTs from 19 Polish MS Centers, who reported at least one adverse event following COVID-19 vaccination. The information was obtained by neurologists using a questionnaire. The same questionnaire was used at all MS Centers. To assess the relevance of reported adverse events, we used Fisher's exact test, Results: A total of 1,668 patients with MS and reports of adverse events after COVID-19 vaccination were finally included in the study. Besides one case marked as "red flag", all adverse events were classified as mild. Pain at the injection site was the most common adverse event, with a greater frequency after the first dose. Pain at the injection site was significantly more frequent after the first dose among individuals with a lower disability (EDSS ≤2). The reported adverse events following immunization did not differ over sex. According to age, pain at the injection site was more common among individuals between 30 and 40 years old, only after the first vaccination dose. None of the DMTs predisposed for particular side effects. Conclusions: According to our findings, vaccination against COVID-19 among patients with MS treated with DMTs is safe. Our study can contribute to reducing hesitancy toward vaccination among patients with MS.

Indexed as

COVID-19multiple sclerosisSARS-CoV-2side effectsvaccination

Identifiers

PMID35775049
PMCPMC9237390
OpenAlexW4282825850

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