Evidence map›Paper›PMID 35775048›Full record

ArticleFrontiers in neurology2022

Detection of Vascular Notch3 Deposits in Unfixed Frozen Skin Biopsy Sample in CADASIL.

Akihiko Ueda, Makoto Nakajima, Yohei Misumi, Keiichi Nakahara, Satoru Shinriki, Masayoshi Tasaki, Hirotaka Matsui, Mitsuharu Ueda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Akihiko UedaDepartment of Neurology, Kumamoto University, Kumamoto, Japan.
Makoto NakajimaDepartment of Neurology, Kumamoto University, Kumamoto, Japan.
Yohei MisumiDepartment of Neurology, Kumamoto University, Kumamoto, Japan.
Keiichi NakaharaDepartment of Neurology, Kumamoto University, Kumamoto, Japan.
Satoru ShinrikiDepartment of Molecular Laboratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Masayoshi TasakiDepartment of Neurology, Kumamoto University, Kumamoto, Japan.
Hirotaka MatsuiDepartment of Molecular Laboratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Mitsuharu UedaDepartment of Neurology, Kumamoto University, Kumamoto, Japan.
Kumamoto University · JPKumamoto Health Science University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the utility of immunohistochemical staining of vascular Notch3 deposits in biopsied unfixed frozen skin samples from patients with suspected cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We analyzed vascular Notch3 deposits in unfixed frozen skin biopsy samples obtained from 43 patients with suspected CADASIL by immunohistochemistry using antibodies against the extracellular domain (ECD) of Notch3. We also sequenced the

Indexed as

CADASILimmunohistochemistryNotch3 depositsNOTCH3 variantsskin biopsy

Identifiers

PMID35775048
PMCPMC9239429
OpenAlexW4282828738

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.