Evidence map›Paper›PMID 35774405›Full record

Trial reportFrontiers in cellular and infection microbiology2022

Intestinal Microbial Composition of Children in a Randomized Controlled Trial of Probiotics to Treat Acute Gastroenteritis.

Rachael G Horne, Stephen B Freedman, Kathene C Johnson-Henry, Xiao-Li Pang, Bonita E Lee, Ken J Farion, Serge Gouin, Suzanne Schuh, Naveen Poonai, Katrina F Hurley and 7 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01853124 (Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01853124 phase3completednot on this map

Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis: Randomized Controlled Trial

TypeinterventionalSponsorDr. Stephen FreedmanRan2013 to 2017Enrolled886ConditionsGastroenteritisArmsPlacebo, Lacidofil
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Understanding the influence of the microbiome on childhood infections.Expert review of anti-infective therapy · 2024
    Review
  2. Host microbiome-pathogen interactions in pediatric infections.Current opinion in infectious diseases · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 1 country.

Rachael G HorneCell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Stephen B FreedmanSections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Kathene C Johnson-HenryCell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Xiao-Li PangAlberta Precision Laboratories - Public Health Laboratory (ProvLab), Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
Bonita E LeeWomen and Children's Research Institute, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
Ken J FarionChildren's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
Serge GouinDepartments of Emergency Medicine and Pediatrics, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Université de Montréal, Montréal, QC, Canada.
Suzanne SchuhDivision of Emergency Medicine, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Naveen PoonaiDivision of Pediatric Emergency Medicine, London Children's Hospital Health Science Centre, Department of Pediatrics, Western University, London, ON, Canada.
Katrina F HurleyPediatric Emergency Medicine, Izaak Walton Killam (IWK) Children's Hospital, Dalhousie University, Halifax, NS, Canada.
Yaron FinkelsteinDivision of Emergency Medicine, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Jianling XiePediatric Emergency Medicine, Izaak Walton Killam (IWK) Children's Hospital, Dalhousie University, Halifax, NS, Canada.
Sarah Williamson-UrquhartSection of Pediatric Emergency Medicine, Department of Pediatrics, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Linda ChuiAlberta Precision Laboratories - Public Health Laboratory (ProvLab), Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
Laura RossiDepartment of Biochemistry and Biomedical Sciences, McMaster University Medical Centre, Hamilton, ON, Canada.
Michael G SuretteDepartment of Biochemistry and Biomedical Sciences, McMaster University Medical Centre, Hamilton, ON, Canada.
Philip M ShermanCell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Hospital for Sick Children · CAIzaak Walton Killam Health Centre · CAMcMaster University Medical Centre · CAUniversity of Alberta · CAAlberta Children's Hospital · CACentre Hospitalier Universitaire Sainte-Justine · CAChildren's Hospital of Eastern Ontario · CALondon Health Sciences Centre · CAProvincial Laboratory of Public Health · CASickKids Foundation · CAUniversity of Calgary · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compositional analysis of the intestinal microbiome in pre-schoolers is understudied. Effects of probiotics on the gut microbiota were evaluated in children under 4-years-old presenting to an emergency department with acute gastroenteritis. Included were 70 study participants (n=32 placebo, n=38 probiotics) with stool specimens at baseline (day 0), day 5, and after a washout period (day 28). Microbiota composition and deduced functions were profiled using 16S ribosomal RNA sequencing and predictive metagenomics, respectively. Probiotics were detected at day 5 of administration but otherwise had no discernable effects, whereas detection of bacterial infection (P<0.001) and participant age (P<0.001) had the largest effects on microbiota composition, microbial diversity, and deduced bacterial functions. Participants under 1 year had lower bacterial diversity than older aged pre-schoolers; compositional changes of individual bacterial taxa were associated with maturation of the gut microbiota. Advances in age were associated with differences in gut microbiota composition and deduced microbial functions, which have the potential to impact health later in life. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT01853124.

Indexed as

GastroenteritisGastrointestinal MicrobiomeMicrobiotaProbioticsChildChild, PreschoolFecesHumansIntestinesRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbacteriachildrengastroenteritisintestinelactobacillusmicrobiomeprobiotics

Identifiers

PMID35774405
PMCPMC9238408
OpenAlexW4282841494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.