Evidence map›Paper›PMID 35774336›Full record

ArticleBiomedical optics express2022

Evaluation of the robustness of cerebral oximetry to variations in skin pigmentation using a tissue-simulating phantom.

Ali Afshari, Rolf B Saager, David Burgos, William C Vogt, Jianting Wang, Gonzalo Mendoza, Sandy Weininger, Kung-Bin Sung, Anthony J Durkin, T Joshua Pfefer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ali AfshariCenter for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA.ORCID https://orcid.org/0000-0003-3065-3638
Rolf B SaagerLinköping Univ., Dept. of Biomedical Engineering, Linköping, Sweden.
David BurgosCenter for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA.
William C VogtCenter for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA.ORCID https://orcid.org/0000-0002-0799-1412
Jianting WangCenter for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA.
Gonzalo MendozaCenter for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA.
Sandy WeiningerCenter for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA.
Kung-Bin SungNational Taiwan University, Graduate Institute of Biomedical Electronics and Bioinformatics, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-7253-1332
Anthony J DurkinDepartment of Biomedical Engineering, University of California, Irvine, 3120 Natural Sciences II, Irvine, California 92697, USA.
T Joshua PfeferCenter for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA.ORCID https://orcid.org/0000-0002-9063-8387

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical studies have demonstrated that epidermal pigmentation level can affect cerebral oximetry measurements. To evaluate the robustness of these devices, we have developed a phantom-based test method that includes an epidermis-simulating layer with several melanin concentrations and a 3D-printed cerebrovascular module. Measurements were performed with neonatal, pediatric and adult sensors from two commercial oximeters, where neonatal probes had shorter source-detector separation distances. Referenced blood oxygenation levels ranged from 30 to 90%. Cerebral oximeter outputs exhibited a consistent decrease in saturation level with simulated melanin content; this effect was greatest at low saturation levels, producing a change of up to 15%. Dependence on pigmentation was strongest in a neonatal sensor, possibly due to its high reflectivity. Overall, our findings indicate that a modular channel-array phantom approach can provide a practical tool for assessing the impact of skin pigmentation on cerebral oximeter performance and that modifications to algorithms and/or instrumentation may be needed to mitigate pigmentation bias.

Identifiers

PMID35774336
PMCPMC9203096

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.