ArticleBiomedical optics express2022
Photoacoustic characterization of bone physico-chemical information.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Tumor survivors' musculoskeletal health assessment: advances in imaging biomarkers for cancer treatment-related sequelae.Journal of orthopaedic surgery and research · 2026Review
- Detecting Collagen by Machine Learning Improved Photoacoustic Spectral Analysis for Breast Cancer Diagnostics: Feasibility Studies With Murine Models.Journal of biophotonics · 2025Article
- Development of a semi-anthropomorphic photoacoustic calcaneus phantom based on nano computed tomography and stereolithography 3D printing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Theoretical and experimental study of attenuation in cancellous bone.Journal of biomedical optics · 2024Article
- Identification of different types of tumors based on photoacoustic spectral analysis: preclinical feasibility studies on skin tumors.Journal of biomedical optics · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis usually alters the chemical composition and physical microstructure of bone. Currently, most clinical techniques for bone assessment are focused on the either bone microstructure or bone mineral density (BMD). In this study, a novel multi-wavelength photoacoustic time-frequency spectral analysis (MWPA-TFSA) method was introduced based on the optical absorption spectra and photoacoustic effects of biological macromolecules, which evaluates changes in bone chemical composition and microstructure. The results demonstrated that osteoporotic bones had decreased BMD, more lipids, and wider trabecular separation filled with larger marrow clusters, which were consistent with multiple gold-standard results, suggesting that the MWPA-TFSA method has the potential to provide a thorough bone physico-chemical information evaluation noninvasively and nonradiatively.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.