Evidence map›Paper›PMID 35774185›Full record

ArticleBrain communications2022

Presurgical temporal lobe epilepsy connectome fingerprint for seizure outcome prediction.

Victoria L Morgan, Lucas E Sainburg, Graham W Johnson, Andrew Janson, Kaela K Levine, Baxter P Rogers, Catie Chang, Dario J Englot

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  16. Towards network-guided neuromodulation for epilepsy.Brain : a journal of neurology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Victoria L MorganInstitute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, R0102 MCN, Nashville, TN 37232, USA.ORCID https://orcid.org/0000-0001-8263-2324
Lucas E SainburgInstitute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, R0102 MCN, Nashville, TN 37232, USA.ORCID https://orcid.org/0000-0003-1508-5871
Graham W JohnsonInstitute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, R0102 MCN, Nashville, TN 37232, USA.
Andrew JansonInstitute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, R0102 MCN, Nashville, TN 37232, USA.
Kaela K LevineInstitute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, R0102 MCN, Nashville, TN 37232, USA.
Baxter P RogersInstitute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, R0102 MCN, Nashville, TN 37232, USA.
Catie ChangInstitute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, R0102 MCN, Nashville, TN 37232, USA.ORCID https://orcid.org/0000-0003-1541-9579
Dario J EnglotInstitute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, R0102 MCN, Nashville, TN 37232, USA.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Relating Vigilance to Connectivity and Neurocognition in Temporal Lobe EpilepsyR01NS112252 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2019 to 2023
$3.0M
The Role of Network Connectivity in Post-Surgical Seizure Recurrence in Temporal Lobe EpilepsyR01NS110130 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2018 to 2023
$2.5M
MRI Connectivity Biomarkers of Treatment Response in Focal EpilepsyR01NS108445 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2019 to 2024
$2.5M
Training Program for Innovative Engineering Research in Surgery and InterventionT32EB021937 · NIBIB · VANDERBILT UNIVERSITY · PI Dario J Englot, Michael Ian Miga · 2016 to 2026
$2.3M
MRI Structural and Functional Connectivity Changes in Temporal Lobe EpilepsyR01NS075270 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2012 to 2016
$1.7M
MULTIMODAL MAPPING OF SUBCORTICAL AND CORTICAL FUNCTIONAL NETWORK DISTURBANCES IN FOCAL EPILEPSYR00NS097618 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2017 to 2019
$743k
NIBIB NIH HHS T32 EB001628NIBIB NIH HHS T32 EB021937NICHD NIH HHS P50 HD103537NINDS NIH HHS R00 NS097618NINDS NIH HHS R01 NS075270NINDS NIH HHS R01 NS108445NINDS NIH HHS R01 NS110130NINDS NIH HHS R01 NS112252
6 · The paper itself

Abstract

Temporal lobe epilepsy presents a unique situation where confident clinical localization of the seizure focus does not always result in a seizure-free or favourable outcome after mesial temporal surgery. In this work, magnetic resonance imaging derived functional and structural whole-brain connectivity was used to compute a network fingerprint that captures the connectivity profile characteristics that are common across a group of nine of these patients with seizure-free outcome. The connectivity profile was then computed for 38 left-out patients with the hypothesis that similarity to the fingerprint indicates seizure-free surgical outcome. Patient profile distance to the fingerprint was compared with 1-year seizure outcome and standard clinical parameters. Distance to the fingerprint was higher for patients with Engel III-IV 1-year outcome compared with those with Engel Ia, Ib-d, and II outcome (Kruskal-Wallis,

Indexed as

magnetic resonance imagingnetworkoutcomeseizuressurgery

Identifiers

PMID35774185
PMCPMC9237708
OpenAlexW4280516636

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.