ArticleBrain communications2022
The cognitive and neural underpinnings of discourse coherence in post-stroke aphasia.
Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 24 citations in OpenAlex.
- The lesion correlates of impaired content word fluency during spoken discourse in aphasia.Brain communications · 2026Article
- Data-driven classification of narrative speech characteristics in stroke aphasia distinguishes neurological and strategic contributions.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Comparing global and local semantic coherence of spontaneous speech in persons with Alzheimer's disease and healthy controls.Applied Corpus Linguistics · 2023Article
- Syntactic Impairment Associated with Hypoperfusion in the Left Middle and Inferior Frontal Gyri after Right Cerebellar Hemorrhage.Internal medicine (Tokyo, Japan) · 2023Article
- Development and Real-Time Clinical Application of New Transcription-Less Discourse Assessment Approaches for Arabic Speakers With Aphasia.International journal of language & communication disordersArticle
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Although impaired discourse production is one of the prominent features of aphasia, only a handful of investigations have addressed the cognitive, linguistic and neural processes that support the production of coherent discourse. In this study, we investigated the cognitive and neural correlates of discourse coherence in a large mixed cohort of patients with post-stroke aphasia, including the first voxel-based lesion-symptom mapping of coherence deficits. Discourse responses using different tasks were collected from 46 patients with post-stroke aphasia, including a wide range of classifications and severity levels, and 20 matched neuro-typical controls. Global coherence, defined as the degree to which utterances related to the expected topic of discourse, was estimated using a previously validated computational linguistic approach. Coherence was then related to fundamental language and cognitive components in aphasia identified using an extensive neuropsychological battery. Relative to neuro-typical controls, patients with aphasia exhibited impaired coherence, and their ability to maintain coherent discourse was related to their performance on other language components: phonological production, fluency and semantic processing, rather than executive functions or motor speech. These results suggest that impairments in core language components play a role in reducing discourse coherence in post-stroke aphasia. Whole-brain voxel-wise lesion-symptom mapping using univariate and multivariate approaches identified the contribution of the left prefrontal cortex, and particularly the inferior frontal gyrus (pars triangularis), to discourse coherence. These findings provide convergent evidence for the role of the inferior frontal gyrus in maintaining discourse coherence, which is consistent with the established role of this region in producing connected speech and semantic control (organizing and selecting appropriate context-relevant concepts). These results make an important contribution to understanding the root causes of disrupted discourse production in post-stroke aphasia.
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