Evidence map›Paper›PMID 35774154›Full record

ArticleChemical science2022

Cold-catalytic antitumor immunity with pyroelectric black phosphorus nanosheets.

Xianbo Wu, Mei Wen, Yuyan Zou, Xinyu Gao, Chuanwan Wei, Renyu Liu, Jianghua Li, Long Wang, Xilong Li, You-Nian Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. S100A5 Attenuates Efficiency of Anti-PD-L1/PD-1 Immunotherapy by Inhibiting CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xianbo WuHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 China chenws@csu.edu.cn.ORCID https://orcid.org/0000-0003-4802-2009
Mei WenHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 China chenws@csu.edu.cn.
Yuyan ZouHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 China chenws@csu.edu.cn.
Xinyu GaoHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 China chenws@csu.edu.cn.
Chuanwan WeiSchool of Chemistry and Chemical Engineering, University of South China Hengyang Hunan 421001 China.
Renyu LiuXiangya Hospital, Central South University Changsha Hunan 410083 China.
Jianghua LiHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 China chenws@csu.edu.cn.
Long WangXiangya Hospital, Central South University Changsha Hunan 410083 China.ORCID https://orcid.org/0000-0002-2733-7370
Xilong LiHefei National Laboratory for Physical Science at Microscale, University of Science and Technology of China Hefei 230026 China.
You-Nian LiuHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 China chenws@csu.edu.cn.ORCID https://orcid.org/0000-0002-7078-5937
Wansong ChenHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 China chenws@csu.edu.cn.ORCID https://orcid.org/0000-0002-3426-2653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Catalytic nanomedicine with the innate features of catalysts brings incomparable properties to biomedicine over traditional drugs. The temperature-dependent activity of catalysts provides catalytic nanomedicines with a facile strategy to control their therapeutic performance. Tuning catalytic nanomedicine by cold treatment (4-37 °C) is safe and desired for practical applications, but there is a lack of cold-catalytic platforms. Herein, with black phosphorus (BP) as a model pyroelectric nanocatalyst, we explored the potential of cold-catalysts for antitumor therapy. BP nanosheets with pyro-catalytic activity catalyze the generation of oxidative stress to activate antitumor immunity under cold treatment. Due to the cold-catalytic immunomodulation, immune memory was successfully achieved to prevent tumor metastasis and recurrence. Considering the safety and conductive depth (>10 mm) of cold in the body, pyroelectric nanocatalysts open up exciting opportunities for the development of cold-catalytic nanomedicine.

Identifiers

PMID35774154
PMCPMC9200116

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.